ANG - Angiogenin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
ANG »  Angiogenin   [ EC 3.1.27.- ]
 
Protein also known as:  Ribonuclease 5 (RNase 5).
Gene name:  ANG
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 151 1
GENE REF ISO

Function

 show evidences
Overview 
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.  
5
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
2
  • UniProtKB
Copper ion bindingdefinition[GO:0005507]  
1
  • UniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Endonuclease activitydefinition[GO:0004519]  
1
  • UniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB
Peptide bindingdefinition[GO:0042277]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
Ribonuclease activitydefinition[GO:0004540]  
2
  • UniProtKB
rRNA bindingdefinition[GO:0019843]  
1
  • UniProtKB
GO biological process 
Actin filament polymerizationdefinition[GO:0030041]  
1
  • Ortholog Curator
Activation of phospholipase A2 activitydefinition[GO:0032431]  
1
  • UniProtKB
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • UniProtKB
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • UniProtKB
Angiogenesisdefinition[GO:0001525]  
4
  • UniProtKB
  • MGI
Cell communicationdefinition[GO:0007154]  
1
  • UniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • UniProtKB
Diacylglycerol biosynthetic processdefinition[GO:0006651]  
1
  • UniProtKB
Homeostatic processdefinition[GO:0042592]  
1
  • UniProtKB
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662]  
1
  • UniProtKB
Negative regulation of translationdefinition[GO:0017148]  
1
  • UniProtKB KW
Nucleic acid phosphodiester bond hydrolysisdefinition[GO:0090305]  
1
  • GOC
Oocyte maturationdefinition[GO:0001556]  
1
  • UniProtKB
Ovarian follicle developmentdefinition[GO:0001541]  
1
  • UniProtKB
Placenta developmentdefinition[GO:0001890]  
1
  • UniProtKB
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
2
  • UniProtKB
Positive regulation of phosphorylationdefinition[GO:0042327]  
1
  • UniProtKB
Positive regulation of protein secretiondefinition[GO:0050714]  
2
  • UniProtKB
  • Ortholog Curator
Response to hormonedefinition[GO:0009725]  
1
  • UniProtKB
Response to hypoxiadefinition[GO:0001666]  
4
  • UniProtKB
RNA phosphodiester bond hydrolysisdefinition[GO:0090501]  
2
  • GOC
rRNA transcriptiondefinition[GO:0009303]  
1
  • UniProtKB
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Stress response  definition   [KW-0346]
Molecular function 
Developmental protein  definition   [KW-0217]
Endonuclease  definition   [KW-0255]
Hydrolase  definition   [KW-0378]
Nuclease  definition   [KW-0540]
Protein synthesis inhibitor  definition   [KW-0652]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Angiogenin
GenomeRNAi: 283
PRO: PR:P03950