ANG - Angiogenin - human protein (Function)
 
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ANG »  Angiogenin   [ EC 3.1.27.- ]
 
Protein also known as:  Ribonuclease 5 (RNase 5).
Gene name:  ANG
Entry whose protein(s) existence is based on evidence at protein level
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1 145 1
GENE REF ISO

Function

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Overview 
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.  
4
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
2
  • IDAUniProtKB
Copper ion bindingdefinition[GO:0005507]  
1
  • IDAUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • ICUniProtKB
Endonuclease activitydefinition[GO:0004519]  
1
  • TASUniProtKB
Endoribonuclease activity, producing 3'-phosphomonoestersdefinition[GO:0016892] silver  
  • IEAInterPro 2 GO
Heparin bindingdefinition[GO:0008201]  
1
  • IDAUniProtKB
Peptide bindingdefinition[GO:0042277]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IDAUniProtKB
Ribonuclease activitydefinition[GO:0004540]  
2
  • IDAUniProtKB
rRNA bindingdefinition[GO:0019843]  
1
  • TASUniProtKB
GO biological process 
Actin filament polymerizationdefinition[GO:0030041]  
  • ISSOrtholog Curator
Activation of phospholipase A2 activitydefinition[GO:0032431]  
1
  • IMPUniProtKB
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • IMPUniProtKB
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • IMPUniProtKB
Angiogenesisdefinition[GO:0001525]  
4
  • IMPUniProtKB
  • IDAMGI
Cell communicationdefinition[GO:0007154]  
1
  • NASUniProtKB
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cell migrationdefinition[GO:0016477]  
1
  • IMPUniProtKB
Diacylglycerol biosynthetic processdefinition[GO:0006651]  
1
  • IDAUniProtKB
Homeostatic processdefinition[GO:0042592]  
1
  • NASUniProtKB
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662]  
1
  • IDAUniProtKB
Negative regulation of translationdefinition[GO:0017148]  
  • IEAUniProtKB KW
Nucleic acid phosphodiester bond hydrolysisdefinition[GO:0090305]  
1
  • TASGOC
Oocyte maturationdefinition[GO:0001556]  
1
  • NASUniProtKB
Ovarian follicle developmentdefinition[GO:0001541]  
1
  • NASUniProtKB
Placenta developmentdefinition[GO:0001890]  
1
  • NASUniProtKB
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
2
  • IDAUniProtKB
Positive regulation of phosphorylationdefinition[GO:0042327]  
1
  • IDAUniProtKB
Positive regulation of protein secretiondefinition[GO:0050714]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Response to hormonedefinition[GO:0009725]  
1
  • IDAUniProtKB
Response to hypoxiadefinition[GO:0001666]  
4
  • IDAUniProtKB
RNA phosphodiester bond hydrolysisdefinition[GO:0090501]  
2
  • IDAGOC
RNA phosphodiester bond hydrolysis, endonucleolyticdefinition[GO:0090502]  
  • IEAInterPro 2 GO
rRNA transcriptiondefinition[GO:0009303]  
1
  • IMPUniProtKB
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Stress response  definition   [KW-0346]
Molecular function 
Developmental protein  definition   [KW-0217]
Endonuclease  definition   [KW-0255]
Hydrolase  definition   [KW-0378]
Nuclease  definition   [KW-0540]
Protein synthesis inhibitor  definition   [KW-0652]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Angiogenin
GenomeRNAi: 283
PRO: PR:P03950