F11 - Coagulation factor XI - human protein (Function)
 
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F11 »  Coagulation factor XI   [ EC 3.4.21.27 ]  (FXI)
 
Protein also known as:  Plasma thromboplastin antecedent (PTA). Cleaved into:  Coagulation factor XIa heavy chain; Coagulation factor XIa light chain.
Gene name:  F11
Entry whose protein(s) existence is based on evidence at protein level
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1 59 2
GENE REF ISO

Function

 show evidences
Overview 
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.  
  • CuratedUniProtKB
GO molecular function 
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Serine-type aminopeptidase activitydefinition[GO:0070009] silver  
  • IEAOrtholog Compara
Serine-type endopeptidase activitydefinition[GO:0004252]  
1
  • NASUniProtKB
GO biological process 
Blood coagulationdefinition[GO:0007596]  
1
  • NASUniProtKB
Plasminogen activationdefinition[GO:0031639]  
1
  • IDABHF-UCL
Positive regulation of fibrinolysisdefinition[GO:0051919]  
1
  • IDABHF-UCL
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.27: Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by SERPINA5.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2160  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Factor_XI
GenomeRNAi: 2160
PRO: PR:P03951
Chemistry
GuidetoPHARMACOLOGY: 2360