KLKB1 - Plasma kallikrein - human protein (Function)
 
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KLKB1 »  Plasma kallikrein   [ EC 3.4.21.34 ]
 
Protein also known as:  Plasma prekallikrein. Cleaved into:  Plasma kallikrein heavy chain; Plasma kallikrein light chain.
Gene name:  KLKB1
Entry whose protein(s) existence is based on evidence at protein level
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1 49 1
GENE REF ISO

Function

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Overview 
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
GO biological process 
Factor XII activationdefinition[GO:0002542]  
1
  • TASBHF-UCL
Fibrinolysisdefinition[GO:0042730]  
  • IEAUniProtKB KW
Plasminogen activationdefinition[GO:0031639]  
1
  • IDABHF-UCL
Positive regulation of fibrinolysisdefinition[GO:0051919]  
1
  • IDABHF-UCL
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Zymogen activationdefinition[GO:0031638]  
1
  • TASBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.34: Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by SERPINA5.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+3818  
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Intrinsic Pathway  REACT_326  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Fibrinolysis  definition   [KW-0280]
Hemostasis  definition   [KW-0356]
Inflammatory response  definition   [KW-0395]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KLKB1
GenomeRNAi: 3818
PRO: PR:P03952