MMP1 - Interstitial collagenase - human protein (Function)
 
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MMP1 »  Interstitial collagenase   [ EC 3.4.24.7 ]
 
Protein also known as:  Matrix metalloproteinase-1 (MMP-1). Cleaved into:  22 kDa interstitial collagenase; 27 kDa interstitial collagenase.
Gene name:  MMP1
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
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1 489 1
GENE REF ISO

Function

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Overview 
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Metalloendopeptidase activitydefinition[GO:0004222]  
1
  • IDABHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.7: Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 4 calcium ions per subunit.  
  • CuratedUniProtKB
Binds 2 zinc ions per subunit.  
  • CuratedUniProtKB
It is regulated in the following manner
Can be activated without removal of the activation peptide.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bladder cancer  hsa05219+4312  
Pathways in cancer  hsa05200+4312  
PPAR signaling pathway  hsa03320+4312  
Rheumatoid arthritis  hsa05323+4312  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_133391  
Extracellular matrix organization  REACT_118779  
Extracellular matrix organization  REACT_132934  
Hemostasis  REACT_604  
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MMP1
GenomeRNAi: 4312
PRO: PR:P03956
Chemistry
GuidetoPHARMACOLOGY: 1628