CAT - Catalase - human protein (Function)
 
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CAT »  Catalase   [ EC 1.11.1.6 ]
 
Gene name:  CAT
Family name: Catalase
Entry whose protein(s) existence is based on evidence at protein level
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1 216 1
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Function

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Overview 
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.  
2
  • UniProtKB
GO molecular function 
Aminoacylase activitydefinition[GO:0004046] silver  
1
  • Ortholog Compara
Antioxidant activitydefinition[GO:0016209]  
1
  • UniProtKB
Catalase activitydefinition[GO:0004096]  
3
  • UniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Heme bindingdefinition[GO:0020037]  
2
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
NADP bindingdefinition[GO:0050661]  
1
  • UniProtKB
Oxidoreductase activity, acting on peroxide as acceptordefinition[GO:0016684]  
1
  • Ortholog Curator
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
2
  • UniProtKB
GO biological process 
Aerobic respirationdefinition[GO:0009060] silver  
1
  • Ortholog Compara
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
1
  • Ortholog Compara
Cholesterol metabolic processdefinition[GO:0008203] silver  
1
  • Ortholog Compara
Hemoglobin metabolic processdefinition[GO:0020027] silver  
1
  • Ortholog Compara
Hydrogen peroxide catabolic processdefinition[GO:0042744]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088] silver  
1
  • Ortholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
1
  • UniProtKB
Positive regulation of cell divisiondefinition[GO:0051781]  
1
  • UniProtKB KW
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092] silver  
1
  • Ortholog Compara
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068] silver  
1
  • Ortholog Compara
Protein homotetramerizationdefinition[GO:0051289]  
1
  • UniProtKB
Protein tetramerizationdefinition[GO:0051262]  
2
  • UniProtKB
Response to hyperoxiadefinition[GO:0055093] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to reactive oxygen speciesdefinition[GO:0000302]  
1
  • UniProtKB
Response to vitamin Edefinition[GO:0033197] silver  
1
  • Ortholog Compara
Triglyceride metabolic processdefinition[GO:0006641] silver  
1
  • Ortholog Compara
Ureteric bud developmentdefinition[GO:0001657] silver  
1
  • Ortholog Compara
UV protectiondefinition[GO:0009650]  
2
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.11.1.6: 2 H(2)O(2) O(2) + 2 H(2)O.  
3
  • UniProtKB
  • PROSITE-ProRule
It requires the following cofactors
 heme  
1
  • UniProtKB
 NADP(+)  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amyotrophic lateral sclerosis (ALS)  hsa05014+847  
Metabolic pathways  hsa01100+847  
Peroxisome  hsa04146+847  
Tryptophan metabolism  hsa00380+847  
According to Reactome, this protein belongs to the following pathways:
Detoxification of Reactive Oxygen Species  REACT_264249  
Purine catabolism  REACT_2086  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen peroxide  definition   [KW-0376]
Molecular function 
Mitogen  definition   [KW-0497]
Oxidoreductase  definition   [KW-0560]
Peroxidase  definition   [KW-0575]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P04040
Other
GeneWiki: Catalase
GenomeRNAi: 847
PRO: PR:P04040