GBA - Glucosylceramidase - human protein (Function)
 
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GBA »  Glucosylceramidase   [ EC 3.2.1.45 ]
 
Protein also known as:  D-glucosyl-N-acylsphingosine glucohydrolase.
Gene name:  GBA
Family name: Glycosyl hydrolase 30
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
Glucosylceramidase activitydefinition[GO:0004348]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • ISSBHF-UCL
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975] silver  
  • IEAInterPro 2 GO
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • IMPBHF-UCL
Ceramide biosynthetic processdefinition[GO:0046513]  
1
  • IMPBHF-UCL
Glucosylceramide catabolic processdefinition[GO:0006680]  
1
  • IMPBHF-UCL
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • ICBHF-UCL
Negative regulation of interleukin-6 productiondefinition[GO:0032715]  
1
  • IDABHF-UCL
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • IMPBHF-UCL
Positive regulation of protein dephosphorylationdefinition[GO:0035307]  
1
  • IMPBHF-UCL
Regulation of water loss via skindefinition[GO:0033561] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to pHdefinition[GO:0009268] silver  
  • IEAOrtholog Compara
Response to testosteronedefinition[GO:0033574] silver  
  • IEAOrtholog Compara
Response to thyroid hormonedefinition[GO:0097066] silver  
  • IEAOrtholog Compara
Skin morphogenesisdefinition[GO:0043589] silver  
  • IEAOrtholog Compara
Sphingosine biosynthetic processdefinition[GO:0046512]  
1
  • IMPBHF-UCL
Termination of signal transductiondefinition[GO:0023021]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.1.45: D-glucosyl-N-acylsphingosine + H(2)O D-glucose + N-acylsphingosine.  
  • CuratedUniProtKB
It is regulated in the following manner
Requires saposin-C and anionic phospholipids for activity.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 30  GH30  
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+2629  
Metabolic pathways  hsa01100+2629  
Other glycan degradation  hsa00511+2629  
Sphingolipid metabolism  hsa00600+2629  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Lipid metabolism  definition   [KW-0443]
Sphingolipid metabolism  definition   [KW-0746]
Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Glucocerebrosidase
GenomeRNAi: 2629
PRO: PR:P04062