PROC - Vitamin K-dependent protein C - human protein (Function)
 
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PROC »  Vitamin K-dependent protein C   [ EC 3.4.21.69 ]
 
Protein also known as:  Blood coagulation factor XIV. Cleaved into:  Activation peptide; Vitamin K-dependent protein C heavy chain; Vitamin K-dependent protein C light chain.
Gene name:  PROC
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Serine-type endopeptidase activitydefinition[GO:0004252]  
1
  • TASUniProtKB
GO biological process 
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of blood coagulationdefinition[GO:0030195]  
1
  • TASUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.69: Degradation of blood coagulation factors Va and VIIIa.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+5624  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Protein_C
GenomeRNAi: 5624
PRO: PR:P04070