ALDOA - Fructose-bisphosphate aldolase A - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ALDOA »  Fructose-bisphosphate aldolase A   [ EC 4.1.2.13 ]
 
Protein also known as:  Lung cancer antigen NY-LU-1.
Gene name:  ALDOA
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 68 2
GENE REF ISO

Function

 show evidences
Overview 
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • TASBHF-UCL
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • IDABHF-UCL
Fructose bindingdefinition[GO:0070061]  
2
  • IDABHF-UCL
Fructose-bisphosphate aldolase activitydefinition[GO:0004332]  
2
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • TASBHF-UCL
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Tubulin bindingdefinition[GO:0015631]  
1
  • TASBHF-UCL
GO biological process 
Actin filament organizationdefinition[GO:0007015]  
1
  • TASBHF-UCL
ATP biosynthetic processdefinition[GO:0006754]  
1
  • IMPBHF-UCL
Fructose 1,6-bisphosphate metabolic processdefinition[GO:0030388]  
2
  • IDABHF-UCL
Fructose metabolic processdefinition[GO:0006000]  
1
  • IMPBHF-UCL
Glycolytic processdefinition[GO:0006096]  
1
  • IMPBHF-UCL
  • IEAUniPathway
Muscle cell cellular homeostasisdefinition[GO:0046716]  
1
  • IMPBHF-UCL
Protein homotetramerizationdefinition[GO:0051289]  
  • ISSOrtholog Curator
Regulation of cell shapedefinition[GO:0008360]  
1
  • IDABHF-UCL
Striated muscle contractiondefinition[GO:0006941]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.2.13: D-fructose 1,6-bisphosphate glycerone phosphate + D-glyceraldehyde 3-phosphate.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fructose and mannose metabolism  hsa00051+226  
Glycolysis / Gluconeogenesis  hsa00010+226  
Metabolic pathways  hsa01100+226  
Pentose phosphate pathway  hsa00030+226  
According to Reactome, this protein belongs to the following pathways:
Gluconeogenesis  REACT_1520  
Glycolysis  REACT_1383  
 
More information is available from:
Note 
In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 52 uM for fructose 1,6-bisphosphate (at 30 degrees Celsius)
Dependence
Temperature Thermal denaturation midpoint (Tm) is 54.4 degrees Celsius.

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P04075
Other
GeneWiki: Aldolase_A
GenomeRNAi: 226
PRO: PR:P04075