ANXA1 - Annexin A1 - human protein (Function)
 
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ANXA1 »  Annexin A1
 
Protein also known as:  Phospholipase A2 inhibitory protein.
Gene name:  ANXA1
Family name: Annexin
Entry whose protein(s) existence is based on evidence at protein level
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1 219 1
GENE REF ISO

Function

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Overview 
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed15187149, PubMed25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed17008549). Has no effect on unstimulated T cells (PubMed17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed2532504, PubMed8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).  
11
  • UniProtKB
According to TCDB this is a transporter from family:
the annexin (annexin) family  1.A.31.1.3  
GO molecular function 
Annealing helicase activitydefinition[GO:0036310] silver  
1
  • Ortholog Compara
Calcium ion bindingdefinition[GO:0005509]  
1
  • Ortholog Curator
Calcium-dependent phospholipid bindingdefinition[GO:0005544]  
1
  • UniProtKB
Calcium-dependent protein bindingdefinition[GO:0048306]  
1
  • AgBase
Double-stranded DNA-dependent ATPase activitydefinition[GO:0033676] silver  
1
  • Ortholog Compara
Helicase activitydefinition[GO:0004386] silver  
1
  • Ortholog Compara
Phospholipase A2 inhibitor activitydefinition[GO:0019834]  
2
  • UniProtKB
  • BHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein binding, bridgingdefinition[GO:0030674]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • PINC
Single-stranded DNA bindingdefinition[GO:0003697] silver  
1
  • Ortholog Compara
Single-stranded RNA bindingdefinition[GO:0003727] silver  
1
  • Ortholog Compara
Structural molecule activitydefinition[GO:0005198]  
1
  • UniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • UniProtKB
Adaptive immune responsedefinition[GO:0002250]  
1
  • UniProtKB KW
Alpha-beta T cell differentiationdefinition[GO:0046632]  
1
  • Ortholog Curator
Arachidonic acid secretiondefinition[GO:0050482] silver  
1
  • Ortholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166] silver  
1
  • Ortholog Compara
Cellular response to glucocorticoid stimulusdefinition[GO:0071385]  
1
  • BHF-UCL
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
1
  • Ortholog Compara
DNA duplex unwindingdefinition[GO:0032508] silver  
1
  • Ortholog Compara
DNA rewindingdefinition[GO:0036292] silver  
1
  • Ortholog Compara
DNA strand renaturationdefinition[GO:0000733] silver  
1
  • Ortholog Compara
Endocrine pancreas developmentdefinition[GO:0031018] silver  
1
  • Ortholog Compara
Estrous cycledefinition[GO:0044849] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
2
  • UniProtKB
Gliogenesisdefinition[GO:0042063] silver  
1
  • Ortholog Compara
Granulocyte chemotaxisdefinition[GO:0071621]  
1
  • UniProtKB
Hepatocyte differentiationdefinition[GO:0070365] silver  
1
  • Ortholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • Ortholog Curator
Innate immune responsedefinition[GO:0045087]  
1
  • UniProtKB KW
Insulin secretiondefinition[GO:0030073] silver  
1
  • Ortholog Compara
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • UniProtKB
Monocyte chemotaxisdefinition[GO:0002548]  
1
  • UniProtKB
Myoblast migration involved in skeletal muscle regenerationdefinition[GO:0014839] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of exocytosisdefinition[GO:0045920]  
1
  • UniProtKB
Negative regulation of interleukin-8 secretiondefinition[GO:2000483]  
1
  • BHF-UCL
Negative regulation of phospholipase A2 activitydefinition[GO:1900138] silver  
1
  • Ortholog Compara
Negative regulation of T-helper 2 cell differentiationdefinition[GO:0045629]  
1
  • UniProtKB
Neutrophil clearancedefinition[GO:0097350]  
1
  • BHF-UCL
Neutrophil homeostasisdefinition[GO:0001780]  
1
  • BHF-UCL
Peptide cross-linkingdefinition[GO:0018149]  
1
  • UniProtKB
Phagocytosisdefinition[GO:0006909]  
1
  • Ortholog Curator
Positive regulation of G1/S transition of mitotic cell cycledefinition[GO:1900087] silver  
1
  • Ortholog Compara
Positive regulation of interleukin-2 productiondefinition[GO:0032743]  
1
  • UniProtKB
Positive regulation of neutrophil apoptotic processdefinition[GO:0033031] silver  
1
  • Ortholog Compara
Positive regulation of prostaglandin biosynthetic processdefinition[GO:0031394] silver  
1
  • Ortholog Compara
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • UniProtKB
Positive regulation of T-helper 1 cell differentiationdefinition[GO:0045627]  
1
  • UniProtKB
Positive regulation of vesicle fusiondefinition[GO:0031340]  
1
  • UniProtKB
Positive regulation of wound healingdefinition[GO:0090303]  
1
  • UniProtKB
Prolactin secretiondefinition[GO:0070459] silver  
1
  • Ortholog Compara
Prostate gland developmentdefinition[GO:0030850] silver  
1
  • Ortholog Compara
Regulation of cell shapedefinition[GO:0008360]  
1
  • UniProtKB
Regulation of hormone secretiondefinition[GO:0046883]  
1
  • UniProtKB
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • Ortholog Curator
Regulation of interleukin-1 productiondefinition[GO:0032652]  
1
  • Ortholog Curator
Regulation of leukocyte migrationdefinition[GO:0002685]  
1
  • Ortholog Curator
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to interleukin-1definition[GO:0070555] silver  
1
  • Ortholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
1
  • Ortholog Compara
Response to X-raydefinition[GO:0010165] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Formyl peptide receptors bind formyl peptides and many other ligands  R-HSA-444473  
G alpha (i) signalling events  R-HSA-418594  
G alpha (q) signalling events  R-HSA-416476  
Muscle contraction  R-HSA-397014  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Phospholipase A2 inhibitor  definition   [KW-0593]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Annexin_A1
GenomeRNAi: 301
PRO: PR:P04083