ANXA1 - Annexin A1 - human protein (Function)
 
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ANXA1 »  Annexin A1
 
Protein also known as:  Phospholipase A2 inhibitory protein.
Gene name:  ANXA1
Family name: Annexin
Entry whose protein(s) existence is based on evidence at protein level
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1 192 1
GENE REF ISO

Function

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Overview 
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the annexin (annexin) family  1.A.31.1.3  
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Calcium-dependent phospholipid bindingdefinition[GO:0005544]  
1
  • IDAUniProtKB
Calcium-dependent protein bindingdefinition[GO:0048306]  
1
  • IPIAgBase
Phospholipase A2 inhibitor activitydefinition[GO:0019834]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein binding, bridgingdefinition[GO:0030674]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • TASPINC
Structural molecule activitydefinition[GO:0005198]  
1
  • IDAUniProtKB
GO biological process 
Alpha-beta T cell differentiationdefinition[GO:0046632]  
  • ISSOrtholog Curator
Arachidonic acid secretiondefinition[GO:0050482] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166] silver  
  • IEAOrtholog Compara
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Cellular response to glucocorticoid stimulusdefinition[GO:0071385]  
1
  • IDABHF-UCL
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
  • IEAOrtholog Compara
Endocrine pancreas developmentdefinition[GO:0031018] silver  
  • IEAOrtholog Compara
Estrous cycle phasedefinition[GO:0060206] silver  
  • IEAOrtholog Compara
Gliogenesisdefinition[GO:0042063] silver  
  • IEAOrtholog Compara
Hepatocyte differentiationdefinition[GO:0070365] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Insulin secretiondefinition[GO:0030073] silver  
  • IEAOrtholog Compara
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • IDAUniProtKB
Negative regulation of acute inflammatory responsedefinition[GO:0002674] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • TASUniProtKB
Negative regulation of catalytic activitydefinition[GO:0043086]  
2
  • IDAGOC
  • IEAOrtholog Compara
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
Negative regulation of interleukin-8 secretiondefinition[GO:2000483]  
1
  • IMPBHF-UCL
Neutrophil clearancedefinition[GO:0097350]  
1
  • IMPBHF-UCL
Neutrophil homeostasisdefinition[GO:0001780]  
1
  • IMPBHF-UCL
Peptide cross-linkingdefinition[GO:0018149]  
1
  • IDAUniProtKB
Positive regulation of G1/S transition of mitotic cell cycledefinition[GO:1900087] silver  
  • IEAOrtholog Compara
Positive regulation of neutrophil apoptotic processdefinition[GO:0033031] silver  
  • IEAOrtholog Compara
Positive regulation of prostaglandin biosynthetic processdefinition[GO:0031394] silver  
  • IEAOrtholog Compara
Positive regulation of vesicle fusiondefinition[GO:0031340]  
1
  • IDAUniProtKB
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to interleukin-1definition[GO:0070555] silver  
  • IEAOrtholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Response to X-raydefinition[GO:0010165] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Formyl peptide receptors bind formyl peptides and many other ligands  REACT_21264  
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
 

Keywords

Molecular function 
Phospholipase A2 inhibitor  definition   [KW-0593]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Annexin_A1
GenomeRNAi: 301
PRO: PR:P04083