APOB - Apolipoprotein B-100 - human protein (Function)
 
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APOB »  Apolipoprotein B-100  (Apo B-100)
 
Cleaved into:  Apolipoprotein B-48.
Gene name:  APOB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.  
  • CuratedUniProtKB
GO molecular function 
Cholesterol transporter activitydefinition[GO:0017127]  
1
  • IMPBHF-UCL
Heparin bindingdefinition[GO:0008201]  
1
  • IDABHF-UCL
Lipase bindingdefinition[GO:0035473]  
1
  • IPIBHF-UCL
Low-density lipoprotein particle receptor bindingdefinition[GO:0050750]  
2
  • IMPBHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
GO biological process 
Artery morphogenesisdefinition[GO:0048844] silver  
  • IEAOrtholog Compara
Cellular response to prostaglandin stimulusdefinition[GO:0071379] silver  
  • IEAOrtholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
  • IEAOrtholog Compara
Cholesterol effluxdefinition[GO:0033344] silver  
  • IEAOrtholog Compara
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • IMPBHF-UCL
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • IMPBHF-UCL
Cholesterol transportdefinition[GO:0030301]  
1
  • IMPBHF-UCL
Fertilizationdefinition[GO:0009566] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Lipoprotein biosynthetic processdefinition[GO:0042158] silver  
  • IEAOrtholog Compara
Lipoprotein catabolic processdefinition[GO:0042159] silver  
  • IEAOrtholog Compara
Lipoprotein transportdefinition[GO:0042953] silver  
  • IEAOrtholog Compara
Low-density lipoprotein particle clearancedefinition[GO:0034383]  
2
  • IMPBHF-UCL
Low-density lipoprotein particle remodelingdefinition[GO:0034374]  
1
  • IMPBHF-UCL
Nervous system developmentdefinition[GO:0007399] silver  
  • IEAOrtholog Compara
Positive regulation of cholesterol storagedefinition[GO:0010886]  
1
  • IDABHF-UCL
Positive regulation of lipid storagedefinition[GO:0010884]  
1
  • IDABHF-UCL
Positive regulation of macrophage derived foam cell differentiationdefinition[GO:0010744]  
3
  • IDABHF-UCL
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Regulation of cholesterol biosynthetic processdefinition[GO:0045540] silver  
  • IEAOrtholog Compara
Response to carbohydratedefinition[GO:0009743] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to selenium iondefinition[GO:0010269] silver  
  • IEAOrtholog Compara
Response to virusdefinition[GO:0009615]  
1
  • IEPUniProtKB
Sperm motilitydefinition[GO:0030317] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Triglyceride catabolic processdefinition[GO:0019433] silver  
  • IEAOrtholog Compara
Triglyceride mobilizationdefinition[GO:0006642] silver  
  • IEAOrtholog Compara
Very-low-density lipoprotein particle assemblydefinition[GO:0034379]  
1
  • ICBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fat digestion and absorption  hsa04975+338  
Vitamin digestion and absorption  hsa04977+338  
According to Reactome, this protein belongs to the following pathways:
Cell surface interactions at the vascular wall  REACT_12051  
Chylomicron-mediated lipid transport  REACT_6841  
LDL-mediated lipid transport  REACT_6934  
Platelet sensitization by LDL  REACT_23879  
Retinoid metabolism and transport  REACT_24968  
Scavenging by Class A Receptors  REACT_163699  
Scavenging by Class B Receptors  REACT_163679  
Scavenging by Class F Receptors  REACT_163813  
Scavenging by Class H Receptors  REACT_164002  
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_B
GenomeRNAi: 338
PRO: PR:P04114