NR3C1 - Glucocorticoid receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
NR3C1 »  Glucocorticoid receptor  (GR)
 
Protein also known as:  Nuclear receptor subfamily 3 group C member 1.
Gene name:  NR3C1
Family name: Nuclear hormone receptor » NR3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 508 9
GENE REF ISO

Function

 show evidences
Overview 
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.  
2
  • CuratedUniProtKB
GO molecular function 
Glucocorticoid receptor activitydefinition[GO:0004883] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
14
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
  • IPIBHF-UCL
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDANTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • IDANTNU_SB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • TASPINC
Steroid bindingdefinition[GO:0005496]  
  • IEAUniProtKB KW
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
  • IEAOrtholog Compara
Chromatin modificationdefinition[GO:0016568]  
  • IEAUniProtKB KW
Glucocorticoid mediated signaling pathwaydefinition[GO:0043402] silver  
  • IEAOrtholog Compara
Glucocorticoid metabolic processdefinition[GO:0008211] silver  
  • IEAOrtholog Compara
Glucocorticoid receptor signaling pathwaydefinition[GO:0042921] silver  
  • IEAOrtholog Compara
Mammary gland duct morphogenesisdefinition[GO:0060603] silver  
  • IEAOrtholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDANTNU_SB
Regulation of glucocorticoid biosynthetic processdefinition[GO:0031946] silver  
  • IEAOrtholog Compara
Regulation of gluconeogenesisdefinition[GO:0006111] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2908  
According to Reactome, this protein belongs to the following pathways:
BMAL1:CLOCK,NPAS2 activates circadian gene expression  REACT_111118  
Nuclear Receptor transcription pathway  REACT_15525  
Note 
Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine polypeptides derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear localization of expanded polyglutamine proteins are regulated cellular processes that can be modulated by this receptor, a well-characterized transcriptional regulator.  
  • CuratedUniProtKB
High constitutive expression of isoform Beta by neutrophils may provide a mechanism by which these cells escape glucocorticoid-induced cell death. Up-regulation by proinflammatory cytokines such as IL8 further enhances their survival in the presence of glucocorticoids during inflammation.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Glucocorticoid_receptor
GenomeRNAi: 2908
PRO: PR:P04150
Chemistry
GuidetoPHARMACOLOGY: 625