NR3C1 - Glucocorticoid receptor - human protein (Function)
 
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NR3C1 »  Glucocorticoid receptor  (GR)
 
Protein also known as:  Nuclear receptor subfamily 3 group C member 1.
Gene name:  NR3C1
Family name: Nuclear hormone receptor » NR3
Entry whose protein(s) existence is based on evidence at protein level
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1 531 9
GENE REF ISO

Function

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Overview 
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.  
3
  • UniProtKB
GO molecular function 
Glucocorticoid receptor activitydefinition[GO:0004883]  
1
  • PINC
Glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activitydefinition[GO:0038051]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
18
  • IntAct
  • UniProtKB
  • HGNC
  • BHF-UCL
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
2
  • UniProtKB
  • NTNU_SB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • UniProtKB
Steroid bindingdefinition[GO:0005496]  
1
  • UniProtKB
Steroid hormone bindingdefinition[GO:1990239]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
1
  • Ortholog Compara
Cellular response to steroid hormone stimulusdefinition[GO:0071383]  
2
  • UniProtKB
Chromatin modificationdefinition[GO:0016568]  
1
  • UniProtKB KW
Glucocorticoid mediated signaling pathwaydefinition[GO:0043402] silver  
1
  • Ortholog Compara
Glucocorticoid metabolic processdefinition[GO:0008211] silver  
1
  • Ortholog Compara
Glucocorticoid receptor signaling pathwaydefinition[GO:0042921] silver  
1
  • Ortholog Compara
Mammary gland duct morphogenesisdefinition[GO:0060603] silver  
1
  • Ortholog Compara
Negative regulation of glucocorticoid mediated signaling pathwaydefinition[GO:1900170] silver  
1
  • Ortholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • UniProtKB
  • NTNU_SB
Regulation of glucocorticoid biosynthetic processdefinition[GO:0031946] silver  
1
  • Ortholog Compara
Regulation of gluconeogenesisdefinition[GO:0006111] silver  
1
  • Ortholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2908  
According to Reactome, this protein belongs to the following pathways:
BMAL1:CLOCK,NPAS2 activates circadian gene expression  REACT_111118  
Nuclear Receptor transcription pathway  REACT_15525  
Note 
Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine polypeptides derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear localization of expanded polyglutamine proteins are regulated cellular processes that can be modulated by this receptor, a well-characterized transcriptional regulator.  
1
  • UniProtKB
High constitutive expression of isoform Beta by neutrophils may provide a mechanism by which these cells escape glucocorticoid-induced cell death. Up-regulation by proinflammatory cytokines such as IL8 further enhances their survival in the presence of glucocorticoids during inflammation.  
1
  • UniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Glucocorticoid_receptor
GenomeRNAi: 2908
PRO: PR:P04150
Chemistry
GuidetoPHARMACOLOGY: 625