MAS1 - Proto-oncogene Mas - human protein (Function)
 
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MAS1 »  Proto-oncogene Mas
 
Gene name:  MAS1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.  
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  • CuratedUniProtKB
GO molecular function 
Angiotensin receptor activitydefinition[GO:0001595]  
  • ISSOrtholog Curator
Angiotensin type II receptor activitydefinition[GO:0004945]  
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  • TASPINC
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • IDAUniProtKB
Peptide bindingdefinition[GO:0042277]  
  • ISSOrtholog Curator
Peptide hormone bindingdefinition[GO:0017046] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of NF-kappaB-inducing kinase activitydefinition[GO:0007250] silver  
  • IEAOrtholog Compara
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • TASPINC
Cell proliferationdefinition[GO:0008283]  
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  • TASPINC
Cellular response to peptide hormone stimulusdefinition[GO:0071375] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Hippocampus developmentdefinition[GO:0021766] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Negative regulation of protein phosphorylationdefinition[GO:0001933] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of DNA replicationdefinition[GO:0045740] silver  
  • IEAOrtholog Compara
Positive regulation of inositol phosphate biosynthetic processdefinition[GO:0060732] silver  
  • IEAOrtholog Compara
Protein kinase C signalingdefinition[GO:0070528]  
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  • IMPUniProtKB
Regulation of inflammatory responsedefinition[GO:0050727] silver  
  • IEAOrtholog Compara
Response to activitydefinition[GO:0014823] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to gonadotropindefinition[GO:0034698] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Neuroactive ligand-receptor interaction  hsa04080+4142  
Renin-angiotensin system  hsa04614+4142  
Caution 
Was originally (PubMed3419518) thought to be a receptor for angiotensin II.  
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  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAS1
GenomeRNAi: 4142
PRO: PR:P04201
Chemistry
GuidetoPHARMACOLOGY: 150