CD3D - T-cell surface glycoprotein CD3 delta chain - human protein (Function)
 
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CD3D »  T-cell surface glycoprotein CD3 delta chain
 
Protein also known as:  T-cell receptor T3 delta chain; CD antigen CD3d.
Gene name:  CD3D
Entry whose protein(s) existence is based on evidence at protein level
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1 39 2
GENE REF ISO

Function

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Overview 
The CD3 complex mediates signal transduction.  
  • CuratedUniProtKB
GO molecular function 
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIUniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • IDAMGI
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • ICUniProtKB
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • ICUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAMGI
Positive thymic T cell selectiondefinition[GO:0045059]  
  • ISSOrtholog Curator
T cell differentiationdefinition[GO:0030217]  
1
  • IDAMGI
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chagas disease (American trypanosomiasis)  hsa05142+915  
Hematopoietic cell lineage  hsa04640+915  
HTLV-I infection  hsa05166+915  
Measles  hsa05162+915  
Primary immunodeficiency  hsa05340+915  
T cell receptor signaling pathway  hsa04660+915  
According to Reactome, this protein belongs to the following pathways:
Downstream TCR signaling  REACT_12555  
Generation of second messenger molecules  REACT_12623  
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell  REACT_11152  
PD-1 signaling  REACT_19324  
Phosphorylation of CD3 and TCR zeta chains  REACT_12582  
Translocation of ZAP-70 to Immunological synapse  REACT_12596  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD3D
GenomeRNAi: 915
PRO: PR:P04234