KRT1 - Keratin, type II cytoskeletal 1 - human protein (Function)
 
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KRT1 »  Keratin, type II cytoskeletal 1
 
Protein also known as:  Type-II keratin Kb1.
Gene name:  KRT1
Family name: Intermediate filament
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.  
3
  • UniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • UniProtKB
Structural molecule activitydefinition[GO:0005198] silver  
1
  • InterPro 2 GO
GO biological process 
Complement activation, lectin pathwaydefinition[GO:0001867]  
1
  • UniProtKB
Establishment of skin barrierdefinition[GO:0061436] silver  
1
  • Ortholog Compara
Fibrinolysisdefinition[GO:0042730]  
1
  • UniProtKB
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
1
  • Ortholog Compara
Regulation of angiogenesisdefinition[GO:0045765]  
1
  • UniProtKB
Response to oxidative stressdefinition[GO:0006979]  
1
  • UniProtKB
Retina homeostasisdefinition[GO:0001895]  
1
  • UniProtKB
Note 
There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).  
1
  • UniProtKB
Caution 
A peptide corresponding to residues 278 to 289 was isolated as part of plant proteomics studies and was originally thought to be of plant origin (PubMed:18602030, PubMed:19412582, PubMed:16529377). However, it was later shown that it is likely to be human type II keratin, a common contaminant in proteomic analyses (PubMed23895828).  
2
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Keratin_1
GenomeRNAi: 3848
PRO: PR:P04264