VWF - von Willebrand factor - human protein (Function)
 
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VWF »  von Willebrand factor  (vWF)
 
Cleaved into:  von Willebrand antigen 2.
Gene name:  VWF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 619 1
GENE REF ISO

Function

 show evidences
Overview 
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.  
  • CuratedUniProtKB
GO molecular function 
Chaperone bindingdefinition[GO:0051087]  
1
  • IDAUniProtKB
Collagen bindingdefinition[GO:0005518]  
1
  • IDAUniProtKB
Glycoprotein bindingdefinition[GO:0001948]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Immunoglobulin bindingdefinition[GO:0019865]  
1
  • IDAUniProtKB
Integrin bindingdefinition[GO:0005178]  
1
  • IPIUniProtKB
Protease bindingdefinition[GO:0002020]  
2
  • IDAMGI
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • IPIUniProtKB
GO biological process 
Blood coagulationdefinition[GO:0007596]  
1
  • IMPUniProtKB
Cell adhesiondefinition[GO:0007155]  
1
  • IDAUniProtKB
Cell-substrate adhesiondefinition[GO:0031589]  
1
  • IDAUniProtKB
Hemostasisdefinition[GO:0007599]  
1
  • IMPUniProtKB
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Placenta developmentdefinition[GO:0001890] silver  
  • IEAOrtholog Compara
Platelet activationdefinition[GO:0030168]  
2
  • NASUniProtKB
Protein homooligomerizationdefinition[GO:0051260]  
1
  • IDAUniProtKB
Response to woundingdefinition[GO:0009611]  
1
  • TASUniProtKB
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+7450  
ECM-receptor interaction  hsa04512+7450  
Focal adhesion  hsa04510+7450  
According to Reactome, this protein belongs to the following pathways:
GP1b-IX-V activation signalling  REACT_23847  
Integrin alphaIIb beta3 signaling  REACT_15523  
Integrin cell surface interactions  REACT_13552  
Intrinsic Pathway  REACT_326  
p130Cas linkage to MAPK signaling for integrins  REACT_15381  
Platelet Adhesion to exposed collagen  REACT_1230  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Cell adhesion  definition   [KW-0130]
Hemostasis  definition   [KW-0356]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Von_Willebrand_factor
GenomeRNAi: 7450
PRO: PR:P04275