WNT1 - Proto-oncogene Wnt-1 - human protein (Function)
 
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WNT1 »  Proto-oncogene Wnt-1
 
Protein also known as:  Proto-oncogene Int-1 homolog.
Gene name:  WNT1
Family name: Wnt
Entry whose protein(s) existence is based on evidence at protein level
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1 124 1
GENE REF ISO

Function

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Overview 
Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.  
1
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • ISSOrtholog Curator
Frizzled bindingdefinition[GO:0005109]  
1
  • ICBHF-UCL
  • IBARefGenome
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Receptor agonist activitydefinition[GO:0048018]  
1
  • ICBHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Bone developmentdefinition[GO:0060348]  
1
  • IMPUniProtKB
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IEAOrtholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
2
  • IMPBHF-UCL
Canonical Wnt signaling pathway involved in negative regulation of apoptotic processdefinition[GO:0044336]  
1
  • IMPBHF-UCL
Cell fate commitmentdefinition[GO:0045165] silver  
  • IBARefGenome
Cell-cell signalingdefinition[GO:0007267]  
  • ISSOrtholog Curator
Cellular response to peptide hormone stimulusdefinition[GO:0071375] silver  
  • IEAOrtholog Compara
Central nervous system morphogenesisdefinition[GO:0021551]  
  • ISSOrtholog Curator
Cerebellum formationdefinition[GO:0021588]  
  • ISSOrtholog Curator
Diencephalon developmentdefinition[GO:0021536] silver  
  • IEAOrtholog Compara
Embryonic axis specificationdefinition[GO:0000578]  
  • ISSOrtholog Curator
Forebrain anterior/posterior pattern specificationdefinition[GO:0021797] silver  
  • IEAOrtholog Compara
Hematopoietic stem cell proliferationdefinition[GO:0071425] silver  
  • IEAOrtholog Compara
Hepatocyte differentiationdefinition[GO:0070365] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Midbrain developmentdefinition[GO:0030901]  
  • ISSOrtholog Curator
Midbrain-hindbrain boundary maturation during brain developmentdefinition[GO:0022004] silver  
  • IEAOrtholog Compara
Myoblast fusiondefinition[GO:0007520] silver  
  • IEAOrtholog Compara
Negative regulation of BMP signaling pathwaydefinition[GO:0030514]  
1
  • IMPAgBase
Negative regulation of cell agingdefinition[GO:0090344]  
1
  • IDABHF-UCL
Negative regulation of cell-cell adhesiondefinition[GO:0022408]  
1
  • IMPBHF-UCL
Negative regulation of cell-substrate adhesiondefinition[GO:0010812]  
1
  • IDABHF-UCL
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
  • ISSOrtholog Curator
Negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:2000059] silver  
  • IEAOrtholog Compara
Negative regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030512] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
  • IBARefGenome
Neuron fate determinationdefinition[GO:0048664] silver  
  • IEAOrtholog Compara
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IMPBHF-UCL
Positive regulation of dermatome developmentdefinition[GO:0061184]  
1
  • IDABHF-UCL
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • IMPBHF-UCL
Positive regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043568]  
1
  • IDABHF-UCL
Positive regulation of lamellipodium assemblydefinition[GO:0010592]  
1
  • IMPBHF-UCL
Positive regulation of Notch signaling pathwaydefinition[GO:0045747]  
1
  • IDABHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IMPUniProtKB
  • IDABHF-UCL
  • ISSOrtholog Curator
Response to woundingdefinition[GO:0009611]  
1
  • IEPUniProtKB
Signal transduction in response to DNA damagedefinition[GO:0042770]  
1
  • IDABHF-UCL
Spemann organizer formationdefinition[GO:0060061]  
  • ISSOrtholog Curator
Spinal cord association neuron differentiationdefinition[GO:0021527] silver  
  • IEAOrtholog Compara
T cell differentiation in thymusdefinition[GO:0033077] silver  
  • IEAOrtholog Compara
Ubiquitin-dependent SMAD protein catabolic processdefinition[GO:0030579] silver  
  • IEAOrtholog Compara
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+7471  
Hedgehog signaling pathway  hsa04340+7471  
HTLV-I infection  hsa05166+7471  
Melanogenesis  hsa04916+7471  
Pathways in cancer  hsa05200+7471  
Wnt signaling pathway  hsa04310+7471  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WNT1
GenomeRNAi: 7471
PRO: PR:P04628