TP53 - Cellular tumor antigen p53 - human protein (Function)
 
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TP53 »  Cellular tumor antigen p53
 
Protein also known as:  Tumor suppressor p53.
Gene name:  TP53
Family name: P53
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.  
11
  • CuratedUniProtKB
Isoform  Iso 7   Inhibits isoform 1-mediated apoptosis.  
11
  • CuratedUniProtKB
Isoform  Iso 2   Enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters.  
11
  • CuratedUniProtKB
Isoform  Iso 4   Suppresses transactivation activity and impairs growth suppression mediated by isoform 1.  
11
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Chaperone bindingdefinition[GO:0051087]  
1
  • IPIUniProtKB
Chromatin bindingdefinition[GO:0003682]  
2
  • IDAMGI
  • IDAUniProtKB
Copper ion bindingdefinition[GO:0005507]  
1
  • IDAUniProtKB
Damaged DNA bindingdefinition[GO:0003684] silver  
  • IBARefGenome
DNA bindingdefinition[GO:0003677]  
1
  • IMPUniProtKB
Enzyme bindingdefinition[GO:0019899]  
8
  • IPIUniProtKB
  • IPIBHF-UCL
Histone acetyltransferase bindingdefinition[GO:0035035]  
2
  • IPIUniProtKB
Histone deacetylase regulator activitydefinition[GO:0035033] silver  
  • IEAOrtholog Compara
Identical protein bindingdefinition[GO:0042802]  
6
  • IPIIntAct
MDM2/MDM4 family protein bindingdefinition[GO:0097371] silver  
  • IEAOrtholog Compara
P53 bindingdefinition[GO:0002039] silver  
  • IBARefGenome
Protease bindingdefinition[GO:0002020]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]