AMY1A - Alpha-amylase 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
AMY1A »  Alpha-amylase 1
 
Gene name:  AMY1A ; AMY1B ; AMY1C
Family name: Glycosyl hydrolase 13
Entry whose protein(s) existence is based on evidence at protein level
extend overview
3 22 1
GENE REF ISO

Function

 show evidences
GO molecular function 
Alpha-amylase activitydefinition[GO:0004556]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
  • IEAUniProtKB KW
Digestiondefinition[GO:0007586]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.1.1: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 calcium ion per subunit.  
  • CuratedUniProtKB
Binds 1 chloride ion per subunit.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 13  GH13  
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Carbohydrate digestion and absorption  hsa04973+276  
Carbohydrate digestion and absorption  hsa04973+278  
Carbohydrate digestion and absorption  hsa04973+277  
Metabolic pathways  hsa01100+278  
Metabolic pathways  hsa01100+276  
Metabolic pathways  hsa01100+277  
Salivary secretion  hsa04970+278  
Salivary secretion  hsa04970+276  
Salivary secretion  hsa04970+277  
Starch and sucrose metabolism  hsa00500+277  
Starch and sucrose metabolism  hsa00500+278  
Starch and sucrose metabolism  hsa00500+276  
According to Reactome, this protein belongs to the following pathway:
Digestion of dietary carbohydrate  REACT_9472  
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AMY1A
PRO: PR:P04745