AMY2A - Pancreatic alpha-amylase - human protein (Function)
 
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Protein
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References

 
AMY2A »  Pancreatic alpha-amylase   [ EC 3.2.1.1 ]  (PA)
 
Protein also known as:  1,4-alpha-D-glucan glucanohydrolase.
Gene name:  AMY2A
Family name: Glycosyl hydrolase 13
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 2
GENE REF ISO

Function

 show evidences
GO molecular function 
Alpha-amylase activitydefinition[GO:0004556]  
1
  • IDAUniProtKB
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
Chloride ion bindingdefinition[GO:0031404]  
1
  • IDAUniProtKB
GO biological process 
Carbohydrate catabolic processdefinition[GO:0016052]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.1.1: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 calcium ion per subunit.  
  • CuratedUniProtKB
Binds 1 chloride ion per subunit.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 13  GH13  
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Carbohydrate digestion and absorption  hsa04973+279  
Metabolic pathways  hsa01100+279  
Pancreatic secretion  hsa04972+279  
Starch and sucrose metabolism  hsa00500+279  
According to Reactome, this protein belongs to the following pathway:
Digestion of dietary carbohydrate  REACT_9472  
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P04746
Other
GeneWiki: AMY2A
GenomeRNAi: 279
PRO: PR:P04746