CYP1A1 - Cytochrome P450 1A1 - human protein (Function)
 
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CYP1A1 »  Cytochrome P450 1A1   [ EC 1.14.14.1 ]
 
Protein also known as:  Cytochrome P450 form 6.
Gene name:  CYP1A1
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
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1 329 3
GENE REF ISO

Function

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Overview 
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.  
  • CuratedUniProtKB
GO molecular function 
Aromatase activitydefinition[GO:0070330]  
  • IEAEC 2 GO
Demethylase activitydefinition[GO:0032451] silver  
  • IEAOrtholog Compara
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Flavonoid 3'-monooxygenase activitydefinition[GO:0016711] silver  
  • IEAOrtholog Compara
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Oxidoreductase activitydefinition[GO:0016491]  
1
  • IDABHF-UCL
Oxidoreductase activity, acting on diphenols and related substances as donorsdefinition[GO:0016679] silver  
  • IEAOrtholog Compara
Oxygen bindingdefinition[GO:0019825]  
1
  • TASPINC
Steroid hydroxylase activitydefinition[GO:0008395] silver  
  • IEAOrtholog Compara
Vitamin D 24-hydroxylase activitydefinition[GO:0070576]  
1
  • IDABHF-UCL
GO biological process 
9-cis-retinoic acid biosynthetic processdefinition[GO:0042904] silver  
  • IEAOrtholog Compara
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Amine metabolic processdefinition[GO:0009308] silver  
  • IEAOrtholog Compara
Camera-type eye developmentdefinition[GO:0043010] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407]  
1
  • IDAMGI
Coumarin metabolic processdefinition[GO:0009804] silver  
  • IEAOrtholog Compara
Demethylationdefinition[GO:0070988] silver  
  • IEAOrtholog Compara
Dibenzo-p-dioxin catabolic processdefinition[GO:0019341] silver  
  • IEAOrtholog Compara
Digestive tract developmentdefinition[GO:0048565] silver  
  • IEAOrtholog Compara
Drug metabolic processdefinition[GO:0017144]  
1
  • IDABHF-UCL
Embryo development ending in birth or egg hatchingdefinition[GO:0009792] silver  
  • IEAOrtholog Compara
Flavonoid metabolic processdefinition[GO:0009812] silver  
  • IEAOrtholog Compara
Hepatocyte differentiationdefinition[GO:0070365] silver  
  • IEAOrtholog Compara
Hydrogen peroxide biosynthetic processdefinition[GO:0050665] silver  
  • IEAOrtholog Compara
Insecticide metabolic processdefinition[GO:0017143] silver  
  • IEAOrtholog Compara
Maternal process involved in parturitiondefinition[GO:0060137] silver  
  • IEAOrtholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDABHF-UCL
Porphyrin-containing compound metabolic processdefinition[GO:0006778] silver  
  • IEAOrtholog Compara
Positive regulation of G1/S transition of mitotic cell cycledefinition[GO:1900087] silver  
  • IEAOrtholog Compara
Response to antibioticdefinition[GO:0046677] silver  
  • IEAOrtholog Compara
Response to arsenic-containing substancedefinition[GO:0046685] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to fooddefinition[GO:0032094] silver  
  • IEAOrtholog Compara
Response to herbicidedefinition[GO:0009635] silver  
  • IEAOrtholog Compara
Response to hyperoxiadefinition[GO:0055093] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to iron(III) iondefinition[GO:0010041] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to nematodedefinition[GO:0009624] silver  
  • IEAOrtholog Compara
Response to virusdefinition[GO:0009615] silver  
  • IEAOrtholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611] silver  
  • IEAOrtholog Compara
Vitamin D metabolic processdefinition[GO:0042359]  
1
  • ICBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.14.1: RH + reduced flavoprotein + O(2) ROH + oxidized flavoprotein + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1543  
Metabolism of xenobiotics by cytochrome P450  hsa00980+1543  
Retinol metabolism  hsa00830+1543  
Steroid hormone biosynthesis  hsa00140+1543  
Tryptophan metabolism  hsa00380+1543  
According to Reactome, this protein belongs to the following pathways:
PPARA activates gene expression  REACT_116145  
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)  REACT_150134  
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)  REACT_150417  
Xenobiotics  REACT_13543  
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P04798
Other
GeneWiki: Cytochrome_P450,_family_1,_member_A1
GenomeRNAi: 1543
PRO: PR:P04798