CYBB - Cytochrome b-245 heavy chain - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CYBB »  Cytochrome b-245 heavy chain   [ EC 1.-.-.- ]
 
Protein also known as:  Superoxide-generating NADPH oxidase heavy chain subunit.
Gene name:  CYBB
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 171 1
GENE REF ISO

Function

 show evidences
Overview 
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the phagocyte (gp91(phox)) nadph oxidase family  5.B.1.1.1  
GO molecular function 
Contributes to electron carrier activitydefinition[GO:0009055]  
1
  • IDABHF-UCL
Flavin adenine dinucleotide bindingdefinition[GO:0050660]  
1
  • IMPBHF-UCL
Heme bindingdefinition[GO:0020037]  
1
  • IMPBHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Contributes to superoxide-generating NADPH oxidase activitydefinition[GO:0016175]  
2
  • TASBHF-UCL
Voltage-gated ion channel activitydefinition[GO:0005244]  
  • IEAUniProtKB KW
GO biological process 
Hydrogen peroxide biosynthetic processdefinition[GO:0050665] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Innate immune responsedefinition[GO:0045087]  
2
  • TASBHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
2
  • TASBHF-UCL
Respiratory burstdefinition[GO:0045730]  
2
  • TASBHF-UCL
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Superoxide anion generationdefinition[GO:0042554]  
2
  • TASBHF-UCL
Superoxide metabolic processdefinition[GO:0006801]  
2
  • TASBHF-UCL
Enzymatic activity 
It requires the following cofactor
FAD (Probable).  
  • CuratedUniProtKB
 
More information is available from:
  • PeroxiBase: 5962 [ HsNOx02 ]
Pathways 
According to KEGG, this protein belongs to the following pathways:
Leukocyte transendothelial migration  hsa04670+1536  
Osteoclast differentiation  hsa04380+1536  
Phagosome  hsa04145+1536  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Oxidoreductase  definition   [KW-0560]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CYBB
GenomeRNAi: 1536
PRO: PR:P04839