GNAI2 - Guanine nucleotide-binding protein G(i) subunit alpha-2 - human protein (Function)
 
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GNAI2 »  Guanine nucleotide-binding protein G(i) subunit alpha-2
 
Protein also known as:  Adenylate cyclase-inhibiting G alpha protein.
Gene name:  GNAI2
Family name: G-alpha » G(i/o/t/z)
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.  
2
  • CuratedUniProtKB
GO molecular function 
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683] silver  
  • IBARefGenome
G-protein coupled receptor bindingdefinition[GO:0001664] silver  
  • IBARefGenome
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
  • IBARefGenome
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Signal transducer activitydefinition[GO:0004871] silver  
  • IBARefGenome
GO biological process 
Activation of MAPKK activitydefinition[GO:0000186] silver  
  • IEAOrtholog Compara
Adenosine receptor signaling pathwaydefinition[GO:0001973] silver  
  • IBARefGenome
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Cell divisiondefinition[GO:0051301]  
1
  • IMPUniProtKB
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007213] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
  • IBARefGenome
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • TASPINC
Negative regulation of synaptic transmissiondefinition[GO:0050805] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transportdefinition[GO:0051924] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
2
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+2771  
Chagas disease (American trypanosomiasis)  hsa05142+2771  
Chemokine signaling pathway  hsa04062+2771  
Cholinergic synapse  hsa04725+2771  
Dopaminergic synapse  hsa04728+2771  
GABAergic synapse  hsa04727+2771  
Gap junction  hsa04540+2771  
Gastric acid secretion  hsa04971+2771  
Glutamatergic synapse  hsa04724+2771  
Leukocyte transendothelial migration  hsa04670+2771  
Long-term depression  hsa04730+2771  
Melanogenesis  hsa04916+2771  
Pertussis  hsa05133+2771  
Progesterone-mediated oocyte maturation  hsa04914+2771  
Tight junction  hsa04530+2771  
Toxoplasmosis  hsa05145+2771  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNAI2
GenomeRNAi: 2771
PRO: PR:P04899