IFNA6 - Interferon alpha-6 - human protein (Function)
 
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IFNA6 »  Interferon alpha-6  (IFN-alpha-6)
 
Protein also known as:  Interferon alpha-54.
Gene name:  IFNA6
Family name: Alpha/beta interferon
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125] silver  
  • IBARefGenome
Type I interferon receptor bindingdefinition[GO:0005132] silver  
  • IBARefGenome
GO biological process 
Adaptive immune responsedefinition[GO:0002250] silver  
  • IBARefGenome
B cell differentiationdefinition[GO:0030183] silver  
  • IBARefGenome
B cell proliferationdefinition[GO:0042100] silver  
  • IBARefGenome
Cytokine-mediated signaling pathwaydefinition[GO:0019221] silver  
  • IBARefGenome
Defense response to virusdefinition[GO:0051607]  
  • IEAUniProtKB KW
Humoral immune responsedefinition[GO:0006959] silver  
  • IBARefGenome
Innate immune responsedefinition[GO:0045087] silver  
  • IBARefGenome
Natural killer cell activation involved in immune responsedefinition[GO:0002323] silver  
  • IBARefGenome
Positive regulation of peptidyl-serine phosphorylation of STAT proteindefinition[GO:0033141] silver  
  • IBARefGenome
Regulation of MHC class I biosynthetic processdefinition[GO:0045343] silver  
  • IBARefGenome
Response to exogenous dsRNAdefinition[GO:0043330] silver  
  • IBARefGenome
T cell activation involved in immune responsedefinition[GO:0002286] silver  
  • IBARefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Autoimmune thyroid disease  hsa05320+3443  
Cytokine-cytokine receptor interaction  hsa04060+3443  
Cytosolic DNA-sensing pathway  hsa04623+3443  
Hepatitis C  hsa05160+3443  
Herpes simplex infection  hsa05168+3443  
Influenza A  hsa05164+3443  
Jak-STAT signaling pathway  hsa04630+3443  
Measles  hsa05162+3443  
Natural killer cell mediated cytotoxicity  hsa04650+3443  
Regulation of autophagy  hsa04140+3443  
RIG-I-like receptor signaling pathway  hsa04622+3443  
Toll-like receptor signaling pathway  hsa04620+3443  
Tuberculosis  hsa05152+3443  
According to Reactome, this protein belongs to the following pathways:
Factors involved in megakaryocyte development and platelet production  REACT_24970  
Interferon alpha/beta signaling  REACT_25162  
Regulation of IFNA signaling  REACT_25216  
TRAF6 mediated IRF7 activation  REACT_24938  
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IFNA6
GenomeRNAi: 3443
PRO: PR:P05013