IGF1 - Insulin-like growth factor I - human protein (Function)
 
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IGF1 »  Insulin-like growth factor I  (IGF-I)
 
Protein also known as:  Mechano growth factor (MGF).
Gene name:  IGF1
Family name: Insulin
Entry whose protein(s) existence is based on evidence at protein level
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1 1031 4
GENE REF ISO

Function

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Overview 
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.  
2
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Hormone activitydefinition[GO:0005179]  
1
  • IDABHF-UCL
Insulin receptor bindingdefinition[GO:0005158]  
1
  • IPIBHF-UCL
Insulin-like growth factor receptor bindingdefinition[GO:0005159]  
1
  • IPIBHF-UCL
Integrin bindingdefinition[GO:0005178]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIBHF-UCL
  • IPIIntAct
GO biological process 
Blood vessel remodelingdefinition[GO:0001974] silver  
  • IEAOrtholog Compara
Bone mineralization involved in bone maturationdefinition[GO:0035630]  
1
  • IDABHF-UCL
Branching morphogenesis of an epithelial tubedefinition[GO:0048754] silver  
  • IEAOrtholog Compara
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Chondroitin sulfate proteoglycan biosynthetic processdefinition[GO:0050650] silver  
  • IEAOrtholog Compara
DNA replicationdefinition[GO:0006260]  
1
  • TASPINC
Exocrine pancreas developmentdefinition[GO:0031017] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IEAOrtholog Compara
Glial cell differentiationdefinition[GO:0010001] silver  
  • IEAOrtholog Compara
Glycolate metabolic processdefinition[GO:0009441]  
1
  • TASPINC
Inner ear developmentdefinition[GO:0048839] silver  
  • IEAOrtholog Compara
Insulin-like growth factor receptor signaling pathwaydefinition[GO:0048009] silver  
  • IEAOrtholog Compara
Lung alveolus developmentdefinition[GO:0048286] silver  
  • IEAOrtholog Compara
Lung lobe morphogenesisdefinition[GO:0060463] silver  
  • IEAOrtholog Compara
Lung vasculature developmentdefinition[GO:0060426] silver  
  • IEAOrtholog Compara
Mammary gland developmentdefinition[GO:0030879] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Muscle hypertrophydefinition[GO:0014896]  
1
  • IMPBHF-UCL
Muscle organ developmentdefinition[GO:0007517]  
1
  • TASPINC
Myoblast differentiationdefinition[GO:0045445]  
1
  • IDABHF-UCL
Myoblast proliferationdefinition[GO:0051450]  
1
  • IDABHF-UCL
Myotube cell developmentdefinition[GO:0014904]  
1
  • IDABHF-UCL
Negative regulation of androgen receptor signaling pathwaydefinition[GO:0060766] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373] silver  
  • IEAOrtholog Compara
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237]  
1
  • IDABHF-UCL
Negative regulation of release of cytochrome c from mitochondriadefinition[GO:0090201]  
  • ISSOrtholog Curator
Negative regulation of smooth muscle cell apoptotic processdefinition[GO:0034392]  
1
  • IDABHF-UCL
Phosphatidylinositol-mediated signalingdefinition[GO:0048015]  
1
  • IDABHF-UCL
Positive regulation of activated T cell proliferationdefinition[GO:0042104]  
1
  • IDABHF-UCL
Positive regulation of calcineurin-NFAT signaling cascadedefinition[GO:0070886]  
1
  • IDAUniProtKB
Positive regulation of cardiac muscle hypertrophydefinition[GO:0010613]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IDABHF-UCL
Positive regulation of cerebellar granule cell precursor proliferationdefinition[GO:0021940] silver  
  • IEAOrtholog Compara
Positive regulation of DNA bindingdefinition[GO:0043388]  
1
  • IDAUniProtKB
Positive regulation of DNA replicationdefinition[GO:0045740]  
2
  • IDABHF-UCL
  • ISSOrtholog Curator
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • IDABHF-UCL
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • IDABHF-UCL
Positive regulation of glucose importdefinition[GO:0046326]  
1
  • IDAUniProtKB
Positive regulation of glycogen biosynthetic processdefinition[GO:0045725]  
1
  • IDAUniProtKB
Positive regulation of glycolytic processdefinition[GO:0045821]  
1
  • IDABHF-UCL
Positive regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043568]  
2
  • IDABHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IDAUniProtKB
Positive regulation of mitosisdefinition[GO:0045840]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of myoblast proliferationdefinition[GO:2000288] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • IDABHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDABHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • IDABHF-UCL
Positive regulation of protein import into nucleus, translocationdefinition[GO:0033160]  
1
  • IDAUniProtKB
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
  • IEAOrtholog Compara
Positive regulation of Ras protein signal transductiondefinition[GO:0046579]  
1
  • IDABHF-UCL
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911]  
1
  • IDABHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
2
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042523]  
1
  • IDABHF-UCL
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisdefinition[GO:0060527] silver  
  • IEAOrtholog Compara
Prostate gland growthdefinition[GO:0060736] silver  
  • IEAOrtholog Compara
Prostate gland stromal morphogenesisdefinition[GO:0060741] silver  
  • IEAOrtholog Compara
Proteoglycan biosynthetic processdefinition[GO:0030166]  
1
  • IDABHF-UCL
Ras protein signal transductiondefinition[GO:0007265]  
1
  • TASPINC
Regulation of establishment or maintenance of cell polaritydefinition[GO:0032878] silver  
  • IEAOrtholog Compara
Regulation of multicellular organism growthdefinition[GO:0040014]  
1
  • IEPBHF-UCL
Satellite cell maintenance involved in skeletal muscle regenerationdefinition[GO:0014834]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Type I pneumocyte differentiationdefinition[GO:0060509] silver  
  • IEAOrtholog Compara
Type II pneumocyte differentiationdefinition[GO:0060510] silver  
  • IEAOrtholog Compara
Water homeostasisdefinition[GO:0030104] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+3479  
Dilated cardiomyopathy  hsa05414+3479  
Focal adhesion  hsa04510+3479  
Glioma  hsa05214+3479  
Hypertrophic cardiomyopathy (HCM)  hsa05410+3479  
Long-term depression  hsa04730+3479  
Melanoma  hsa05218+3479  
mTOR signaling pathway  hsa04150+3479  
Oocyte meiosis  hsa04114+3479  
p53 signaling pathway  hsa04115+3479  
Pathways in cancer  hsa05200+3479  
Progesterone-mediated oocyte maturation  hsa04914+3479  
Prostate cancer  hsa05215+3479  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Metabolism of proteins  REACT_17015  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links