ATP1A1 - Sodium/potassium-transporting ATPase subunit alpha-1 - human protein (Function)
 
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ATP1A1 »  Sodium/potassium-transporting ATPase subunit alpha-1   [ EC 3.6.3.9 ]  (Na(+)/K(+) ATPase alpha-1 subunit)
 
Protein also known as:  Sodium pump subunit alpha-1.
Gene name:  ATP1A1
Entry whose protein(s) existence is based on evidence at protein level
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1 54 4
GENE REF ISO

Function

 show evidences
Overview 
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.1.1  
GO molecular function 
ADP bindingdefinition[GO:0043531] silver  
  • IEAOrtholog Compara
Ankyrin bindingdefinition[GO:0030506] silver  
  • IEAOrtholog Compara
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Chaperone bindingdefinition[GO:0051087]  
  • ISSOrtholog Curator
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548] silver  
  • IEAOrtholog Compara
Potassium ion bindingdefinition[GO:0030955] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Sodium ion bindingdefinition[GO:0031402] silver  
  • IEAOrtholog Compara
Sodium:potassium-exchanging ATPase activitydefinition[GO:0005391]  
  • ISSOrtholog Curator
GO biological process 
ATP biosynthetic processdefinition[GO:0006754] silver  
  • IEAInterPro 2 GO
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Membrane hyperpolarizationdefinition[GO:0060081] silver  
  • IEAOrtholog Compara
Negative regulation of glucocorticoid biosynthetic processdefinition[GO:0031947] silver  
  • IEAOrtholog Compara
Negative regulation of heart contractiondefinition[GO:0045822] silver  
  • IEAOrtholog Compara
Positive regulation of heart contractiondefinition[GO:0045823] silver  
  • IEAOrtholog Compara
Positive regulation of striated muscle contractiondefinition[GO:0045989] silver  
  • IEAOrtholog Compara
Potassium ion importdefinition[GO:0010107] silver  
  • IEAOrtholog Compara
Regulation of blood pressuredefinition[GO:0008217] silver  
  • IEAOrtholog Compara
Regulation of cardiac muscle cell contractiondefinition[GO:0086004] silver  
  • IEAOrtholog Compara
Regulation of sodium ion transportdefinition[GO:0002028]  
  • ISSOrtholog Curator
Regulation of the force of heart contractiondefinition[GO:0002026] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • TASGOC
  • IEAEC 2 GO
  • ISSOrtholog Curator
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.9: ATP + H(2)O + Na(+)(In) + K(+)(Out) ADP + phosphate + Na(+)(Out) + K(+)(In).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+476  
Bile secretion  hsa04976+476  
Carbohydrate digestion and absorption  hsa04973+476  
Cardiac muscle contraction  hsa04260+476  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+476  
Gastric acid secretion  hsa04971+476  
Mineral absorption  hsa04978+476  
Pancreatic secretion  hsa04972+476  
Protein digestion and absorption  hsa04974+476  
Proximal tubule bicarbonate reclamation  hsa04964+476  
Salivary secretion  hsa04970+476  
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Sodium/potassium transport  definition   [KW-0740]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ATPase,_Na%2B/K%2B_transporting,_alpha_1
GenomeRNAi: 476
PRO: PR:P05023
Chemistry
GuidetoPHARMACOLOGY: 833