ATP1B1 - Sodium/potassium-transporting ATPase subunit beta-1 - human protein (Function)
 
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ATP1B1 »  Sodium/potassium-transporting ATPase subunit beta-1
 
Protein also known as:  Sodium/potassium-dependent ATPase subunit beta-1.
Gene name:  ATP1B1
Entry whose protein(s) existence is based on evidence at protein level
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1 23 2
GENE REF ISO

Function

 show evidences
Overview 
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.  
1
  • CuratedUniProtKB
Involved in cell adhesion and establishing epithelial cell polarity.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.1.1  
GO molecular function 
MHC class II protein complex bindingdefinition[GO:0023026]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
Sodium:potassium-exchanging ATPase activitydefinition[GO:0005391] silver  
  • IEAOrtholog Compara
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • TASGOC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+481  
Bile secretion  hsa04976+481  
Carbohydrate digestion and absorption  hsa04973+481  
Cardiac muscle contraction  hsa04260+481  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+481  
Gastric acid secretion  hsa04971+481  
Mineral absorption  hsa04978+481  
Pancreatic secretion  hsa04972+481  
Protein digestion and absorption  hsa04974+481  
Proximal tubule bicarbonate reclamation  hsa04964+481  
Salivary secretion  hsa04970+481  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Sodium/potassium transport  definition   [KW-0740]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP1B1
GenomeRNAi: 481
PRO: PR:P05026