ATP1B1 - Sodium/potassium-transporting ATPase subunit beta-1 - human protein (Function)
 
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ATP1B1 »  Sodium/potassium-transporting ATPase subunit beta-1
 
Protein also known as:  Sodium/potassium-dependent ATPase subunit beta-1.
Gene name:  ATP1B1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 2
GENE REF ISO

Function

 show evidences
Overview 
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.  
2
  • UniProtKB
Involved in cell adhesion and establishing epithelial cell polarity.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.1.1  
GO molecular function 
ATPase activator activitydefinition[GO:0001671]  
1
  • BHF-UCL
ATPase bindingdefinition[GO:0051117]  
1
  • BHF-UCL
MHC class II protein complex bindingdefinition[GO:0023026]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
  • BHF-UCL
Contributes to sodium:potassium-exchanging ATPase activitydefinition[GO:0005391]  
2
  • BHF-UCL
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • Ortholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Cell communication by electrical coupling involved in cardiac conductiondefinition[GO:0086064]  
1
  • BHF-UCL
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • Ortholog Curator
Cellular potassium ion homeostasisdefinition[GO:0030007]  
2
  • BHF-UCL
Cellular sodium ion homeostasisdefinition[GO:0006883]  
2
  • BHF-UCL
Membrane repolarizationdefinition[GO:0086009]  
1
  • BHF-UCL
Membrane repolarization during cardiac muscle cell action potentialdefinition[GO:0086013]  
1
  • BHF-UCL
Positive regulation of ATP catabolic processdefinition[GO:1903291]  
1
  • BHF-UCL
Positive regulation of ATPase activitydefinition[GO:0032781]  
1
  • BHF-UCL
Positive regulation of calcium:sodium antiporter activitydefinition[GO:1903281]  
1
  • Ortholog Curator
Positive regulation of potassium ion importdefinition[GO:1903288]  
1
  • BHF-UCL
Positive regulation of potassium ion transmembrane transporter activitydefinition[GO:1901018]  
1
  • BHF-UCL
Positive regulation of sodium ion export from celldefinition[GO:1903278]  
1
  • BHF-UCL
Potassium ion importdefinition[GO:0010107]  
2
  • BHF-UCL
Protein localization to plasma membranedefinition[GO:0072659]  
1
  • BHF-UCL
Protein stabilizationdefinition[GO:0050821]  
2
  • BHF-UCL
  • Ortholog Curator
Protein transport into plasma membrane raftdefinition[GO:0044861]  
1
  • BHF-UCL
Regulation of cardiac muscle contraction by calcium ion signalingdefinition[GO:0010882]  
1
  • Ortholog Curator
Regulation of gene expressiondefinition[GO:0010468]  
1
  • Ortholog Curator
Relaxation of cardiac muscledefinition[GO:0055119]  
1
  • Ortholog Curator
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Sodium ion export from celldefinition[GO:0036376]  
2
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+481  
Bile secretion  hsa04976+481  
Carbohydrate digestion and absorption  hsa04973+481  
Cardiac muscle contraction  hsa04260+481  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+481  
Gastric acid secretion  hsa04971+481  
Mineral absorption  hsa04978+481  
Pancreatic secretion  hsa04972+481  
Protein digestion and absorption  hsa04974+481  
Proximal tubule bicarbonate reclamation  hsa04964+481  
Salivary secretion  hsa04970+481  
According to Reactome, this protein belongs to the following pathways:
Basigin interactions  REACT_12560  
Ion transport by P-type ATPases  REACT_25149  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Sodium/potassium transport  definition   [KW-0740]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP1B1
GenomeRNAi: 481
PRO: PR:P05026