APOD - Apolipoprotein D - human protein (Function)
 
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APOD »  Apolipoprotein D  (ApoD)
 
Gene name:  APOD
Family name: Calycin » Lipocalin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.  
  • CuratedUniProtKB
GO molecular function 
Cholesterol bindingdefinition[GO:0015485]  
1
  • IDAUniProtKB
Lipid transporter activitydefinition[GO:0005319]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Agingdefinition[GO:0007568]  
1
  • NASUniProtKB
Angiogenesisdefinition[GO:0001525]  
1
  • NASUniProtKB
Brain developmentdefinition[GO:0007420]  
  • ISSOrtholog Curator
Glucose metabolic processdefinition[GO:0006006]  
1
  • IDAUniProtKB
Lipid metabolic processdefinition[GO:0006629]  
1
  • IDAUniProtKB
Lipid transportdefinition[GO:0006869]  
1
  • NASGOC
Negative regulation of cytokine production involved in inflammatory responsedefinition[GO:1900016]  
1
  • IDAUniProtKB
Negative regulation of focal adhesion assemblydefinition[GO:0051895]  
1
  • IMPUniProtKB
Negative regulation of lipoprotein lipid oxidationdefinition[GO:0060588]  
1
  • IDAUniProtKB
Negative regulation of monocyte chemotactic protein-1 productiondefinition[GO:0071638]  
1
  • IDAUniProtKB
Negative regulation of platelet-derived growth factor receptor signaling pathwaydefinition[GO:0010642]  
1
  • IDAUniProtKB
Negative regulation of protein import into nucleusdefinition[GO:0042308]  
1
  • IDAUniProtKB
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662]  
1
  • IDAUniProtKB
Negative regulation of smooth muscle cell-matrix adhesiondefinition[GO:2000098]  
1
  • IMPUniProtKB
Negative regulation of T cell migrationdefinition[GO:2000405]  
1
  • IDAUniProtKB
Peripheral nervous system axon regenerationdefinition[GO:0014012]  
  • ISSOrtholog Curator
Response to axon injurydefinition[GO:0048678]  
  • ISSOrtholog Curator
Response to drugdefinition[GO:0042493]  
  • ISSOrtholog Curator
Response to reactive oxygen speciesdefinition[GO:0000302]  
1
  • IDAUniProtKB
Tissue regenerationdefinition[GO:0042246]  
  • ISSOrtholog Curator
Note 
APOD is primarily localized in HDL (60-65%), with most of the remainder in VHDL and only trace amounts in VLDL and LDL.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_D
GenomeRNAi: 347
PRO: PR:P05090