ALDH2 - Aldehyde dehydrogenase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
ALDH2 »  Aldehyde dehydrogenase, mitochondrial   [ EC 1.2.1.3 ]
 
Protein also known as:  ALDH class 2.
Gene name:  ALDH2
Family name: Aldehyde dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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1 197 2
GENE REF ISO

Function

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GO molecular function 
Aldehyde dehydrogenase [NAD(P)+] activitydefinition[GO:0004030]  
1
  • TASPINC
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
GO biological process 
Alcohol metabolic processdefinition[GO:0006066]  
1
  • TASPINC
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • TASPINC
Ethanol catabolic processdefinition[GO:0006068]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.2.1.3: An aldehyde + NAD(+) + H(2)O a carboxylate + NADH.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+217  
Ascorbate and aldarate metabolism  hsa00053+217  
beta-Alanine metabolism  hsa00410+217  
Fatty acid metabolism  hsa00071+217  
Glycerolipid metabolism  hsa00561+217  
Glycolysis / Gluconeogenesis  hsa00010+217  
Histidine metabolism  hsa00340+217  
Lysine degradation  hsa00310+217  
Metabolic pathways  hsa01100+217  
Pentose and glucuronate interconversions  hsa00040+217  
Propanoate metabolism  hsa00640+217  
Pyruvate metabolism  hsa00620+217  
Tryptophan metabolism  hsa00380+217  
Valine, leucine and isoleucine degradation  hsa00280+217  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P05091
Other
GeneWiki: ALDH2
GenomeRNAi: 217
PRO: PR:P05091
Chemistry
GuidetoPHARMACOLOGY: 2595