CYP17A1 - Steroid 17-alpha-hydroxylase/17,20 lyase - human protein (Function)
 
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CYP17A1 »  Steroid 17-alpha-hydroxylase/17,20 lyase   [ EC 4.1.2.30EC 1.14.99.9 ]
 
Protein also known as:  17-alpha-hydroxyprogesterone aldolase.
Gene name:  CYP17A1
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.  
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  • CuratedUniProtKB
GO molecular function 
17-alpha-hydroxyprogesterone aldolase activitydefinition[GO:0047442]  
  • IEAEC 2 GO
Heme bindingdefinition[GO:0020037]  
1
  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Oxygen bindingdefinition[GO:0019825]  
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  • TASPINC
Steroid 17-alpha-monooxygenase activitydefinition[GO:0004508]  
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  • IDAUniProtKB
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
  • IEAOrtholog Compara
Biphenyl metabolic processdefinition[GO:0018879] silver  
  • IEAOrtholog Compara
Cellular response to antibioticdefinition[GO:0071236] silver  
  • IEAOrtholog Compara
Cellular response to gonadotropin stimulusdefinition[GO:0071371] silver  
  • IEAOrtholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Dibenzo-p-dioxin metabolic processdefinition[GO:0018894] silver  
  • IEAOrtholog Compara
Hippocampus developmentdefinition[GO:0021766] silver  
  • IEAOrtholog Compara
Hormone biosynthetic processdefinition[GO:0042446]  
1
  • IDAUniProtKB
Leydig cell differentiationdefinition[GO:0033327] silver  
  • IEAOrtholog Compara
Ovulationdefinition[GO:0030728] silver  
  • IEAOrtholog Compara
Phenol-containing compound metabolic processdefinition[GO:0018958] silver  
  • IEAOrtholog Compara
Phthalate metabolic processdefinition[GO:0018963] silver  
  • IEAOrtholog Compara
Positive regulation of steroid hormone biosynthetic processdefinition[GO:0090031] silver  
  • IEAOrtholog Compara
Progesterone metabolic processdefinition[GO:0042448]  
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  • IDAUniProtKB
Response to acetatedefinition[GO:0010034] silver  
  • IEAOrtholog Compara
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to cytokinedefinition[GO:0034097] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to fungicidedefinition[GO:0060992] silver  
  • IEAOrtholog Compara
Response to herbicidedefinition[GO:0009635] silver  
  • IEAOrtholog Compara
Response to insecticidedefinition[GO:0017085] silver  
  • IEAOrtholog Compara
Response to ionizing radiationdefinition[GO:0010212] silver  
  • IEAOrtholog Compara
Response to methylmercurydefinition[GO:0051597] silver  
  • IEAOrtholog Compara
Response to nutrient levelsdefinition[GO:0031667] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Response to steroid hormonedefinition[GO:0048545] silver  
  • IEAOrtholog Compara
Sex differentiationdefinition[GO:0007548]  
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  • TASPINC
Steroid biosynthetic processdefinition[GO:0006694]  
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  • TASPINC
Steroid metabolic processdefinition[GO:0008202]  
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  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.14.99.9: A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O(2) a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H(2)O.  
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  • CuratedUniProtKB
EC 4.1.2.30: 17-alpha-hydroxyprogesterone androst-4-ene-3,17-dione + acetaldehyde.  
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  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
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  • CuratedUniProtKB
It is regulated in the following manner
Regulated predominantly by intracellular cAMP levels.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1586  
Steroid hormone biosynthesis  hsa00140+1586  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Steroid hormones  REACT_15493  
 
More information is available from:
 

Keywords

Biological process 
Steroidogenesis  definition   [KW-0755]
Molecular function 
Lyase  definition   [KW-0456]
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P05093
Other
GeneWiki: CYP17A1
GenomeRNAi: 1586
PRO: PR:P05093
Chemistry
GuidetoPHARMACOLOGY: 1361