CYP11A1 - Cholesterol side-chain cleavage enzyme, mitochondrial - human protein (Function)
 
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CYP11A1 »  Cholesterol side-chain cleavage enzyme, mitochondrial   [ EC 1.14.15.6 ]
 
Protein also known as:  Cholesterol desmolase.
Gene name:  CYP11A1
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
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1 79 2
GENE REF ISO

Function

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Overview 
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.  
1
  • CuratedUniProtKB
GO molecular function 
Cholesterol bindingdefinition[GO:0015485] silver  
  • IEAOrtholog Compara
Cholesterol monooxygenase (side-chain-cleaving) activitydefinition[GO:0008386]  
3
  • IDAUniProtKB
  • ISSOrtholog Curator
Heme bindingdefinition[GO:0020037]  
1
  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
GO biological process 
Biphenyl metabolic processdefinition[GO:0018879] silver  
  • IEAOrtholog Compara
C21-steroid hormone biosynthetic processdefinition[GO:0006700]  
3
  • IDAUniProtKB
Cellular response to antibioticdefinition[GO:0071236] silver  
  • IEAOrtholog Compara
Cellular response to cadmium iondefinition[GO:0071276] silver  
  • IEAOrtholog Compara
Cellular response to cAMPdefinition[GO:0071320] silver  
  • IEAOrtholog Compara
Cellular response to fibroblast growth factor stimulusdefinition[GO:0044344] silver  
  • IEAOrtholog Compara
Cellular response to follicle-stimulating hormone stimulusdefinition[GO:0071372] silver  
  • IEAOrtholog Compara
Cellular response to interleukin-1definition[GO:0071347] silver  
  • IEAOrtholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Cellular response to peptide hormone stimulusdefinition[GO:0071375] silver  
  • IEAOrtholog Compara
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560] silver  
  • IEAOrtholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
  • IEAOrtholog Compara
Cerebellum developmentdefinition[GO:0021549] silver  
  • IEAOrtholog Compara
Cholesterol metabolic processdefinition[GO:0008203]  
2
  • IDAUniProtKB
  • ISSOrtholog Curator
Dibenzo-p-dioxin metabolic processdefinition[GO:0018894] silver  
  • IEAOrtholog Compara
Estrogen biosynthetic processdefinition[GO:0006703] silver  
  • IEAOrtholog Compara
Fractalkine metabolic processdefinition[GO:0050756] silver  
  • IEAOrtholog Compara
Granulosa cell differentiationdefinition[GO:0060014] silver  
  • IEAOrtholog Compara
Hippocampus developmentdefinition[GO:0021766] silver  
  • IEAOrtholog Compara
Leydig cell differentiationdefinition[GO:0033327] silver  
  • IEAOrtholog Compara
Maternal process involved in female pregnancydefinition[GO:0060135] silver  
  • IEAOrtholog Compara
Mating behaviordefinition[GO:0007617] silver  
  • IEAOrtholog Compara
Phenol-containing compound metabolic processdefinition[GO:0018958] silver  
  • IEAOrtholog Compara
Phthalate metabolic processdefinition[GO:0018963] silver  
  • IEAOrtholog Compara
Progesterone biosynthetic processdefinition[GO:0006701] silver  
  • IEAOrtholog Compara
Response to aciddefinition[GO:0001101] silver  
  • IEAOrtholog Compara
Response to alkaloiddefinition[GO:0043279] silver  
  • IEAOrtholog Compara
Response to corticosteronedefinition[GO:0051412] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to fungicidedefinition[GO:0060992] silver  
  • IEAOrtholog Compara
Response to gamma radiationdefinition[GO:0010332] silver  
  • IEAOrtholog Compara
Response to genisteindefinition[GO:0033595] silver  
  • IEAOrtholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Response to insecticidedefinition[GO:0017085] silver  
  • IEAOrtholog Compara
Response to L-ascorbic aciddefinition[GO:0033591] silver  
  • IEAOrtholog Compara
Response to salt stressdefinition[GO:0009651] silver  
  • IEAOrtholog Compara
Response to vitamin Edefinition[GO:0033197] silver  
  • IEAOrtholog Compara
Schwann cell differentiationdefinition[GO:0014037] silver  
  • IEAOrtholog Compara
Testosterone biosynthetic processdefinition[GO:0061370] silver  
  • IEAOrtholog Compara
Vitamin D metabolic processdefinition[GO:0042359]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.15.6: Cholesterol + 6 reduced adrenodoxin + 3 O(2) pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H(2)O.  
1
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1583  
Steroid hormone biosynthesis  hsa00140+1583  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Steroid hormones  REACT_15493  
 
More information is available from:
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Steroidogenesis  definition   [KW-0755]
Sterol metabolism  definition   [KW-1207]
Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P05108
Other
GeneWiki: Cholesterol_side-chain_cleavage_enzyme
GenomeRNAi: 1583
PRO: PR:P05108