INHA - Inhibin alpha chain - human protein (Function)
 
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INHA »  Inhibin alpha chain
 
Gene name:  INHA
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 115 1
GENE REF ISO

Function

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Overview 
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • TASUniProtKB
Growth factor activitydefinition[GO:0008083]  
1
  • TASUniProtKB
Hormone activitydefinition[GO:0005179]  
1
  • TASUniProtKB
Inhibin bindingdefinition[GO:0034711] silver  
  • IEAOrtholog Compara
Contributes to protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • IPIHGNC
GO biological process 
Cell cycle arrestdefinition[GO:0007050]  
1
  • TASUniProtKB
Cell differentiationdefinition[GO:0030154]  
1
  • TASUniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASUniProtKB
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASUniProtKB
Erythrocyte differentiationdefinition[GO:0030218]  
1
  • NASUniProtKB
Hemoglobin biosynthetic processdefinition[GO:0042541]  
1
  • IDAUniProtKB
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Negative regulation of B cell differentiationdefinition[GO:0045578]  
1
  • TASUniProtKB
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • TASUniProtKB
Negative regulation of follicle-stimulating hormone secretiondefinition[GO:0046882]  
1
  • NASUniProtKB
Negative regulation of interferon-gamma biosynthetic processdefinition[GO:0045077]  
1
  • TASUniProtKB
Negative regulation of macrophage differentiationdefinition[GO:0045650]  
1
  • TASUniProtKB
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • TASUniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • NASUniProtKB
Ovarian follicle developmentdefinition[GO:0001541]  
1
  • NASUniProtKB
Positive regulation of follicle-stimulating hormone secretiondefinition[GO:0046881]  
1
  • TASUniProtKB
Regulation of cell cycledefinition[GO:0051726]  
1
  • IDAHGNC
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • IDAHGNC
Response to external stimulusdefinition[GO:0009605]  
1
  • TASUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Glycoprotein hormones  REACT_15398  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: INHA
GenomeRNAi: 3623
PRO: PR:P05111