INHA - Inhibin alpha chain - human protein (Function)
 
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INHA »  Inhibin alpha chain
 
Gene name:  INHA
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 119 1
GENE REF ISO

Function

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Overview 
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.  
1
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • UniProtKB
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB
Hormone activitydefinition[GO:0005179]  
1
  • UniProtKB
Inhibin bindingdefinition[GO:0034711] silver  
1
  • Ortholog Compara
Contributes to protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • HGNC
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
1
  • RefGenome
GO biological process 
Cell cycle arrestdefinition[GO:0007050]  
1
  • UniProtKB
Cell developmentdefinition[GO:0048468]  
1
  • RefGenome
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • UniProtKB
Cell-cell signalingdefinition[GO:0007267]  
1
  • UniProtKB
Erythrocyte differentiationdefinition[GO:0030218]  
1
  • UniProtKB
Hemoglobin biosynthetic processdefinition[GO:0042541]  
1
  • UniProtKB
Male gonad developmentdefinition[GO:0008584] silver  
1
  • Ortholog Compara
Negative regulation of B cell differentiationdefinition[GO:0045578]  
1
  • UniProtKB
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • UniProtKB
Negative regulation of follicle-stimulating hormone secretiondefinition[GO:0046882]  
1
  • UniProtKB
Negative regulation of interferon-gamma biosynthetic processdefinition[GO:0045077]  
1
  • UniProtKB
Negative regulation of macrophage differentiationdefinition[GO:0045650]  
1
  • UniProtKB
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • UniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • UniProtKB
Ovarian follicle developmentdefinition[GO:0001541]  
1
  • UniProtKB
Positive regulation of follicle-stimulating hormone secretiondefinition[GO:0046881]  
1
  • UniProtKB
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • RefGenome
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • RefGenome
Regulation of cell cycledefinition[GO:0051726]  
1
  • HGNC
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • HGNC
Regulation of MAPK cascadedefinition[GO:0043408]  
1
  • RefGenome
Response to external stimulusdefinition[GO:0009605]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Skeletal system developmentdefinition[GO:0001501]  
1
  • PINC
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • RefGenome
Pathways 
According to Reactome, this protein belongs to the following pathway:
Glycoprotein hormones  REACT_15398  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: INHA
GenomeRNAi: 3623
PRO: PR:P05111