SERPINB2 - Plasminogen activator inhibitor 2 - human protein (Function)
 
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SERPINB2 »  Plasminogen activator inhibitor 2  (PAI-2)
 
Protein also known as:  Placental plasminogen activator inhibitor.
Gene name:  SERPINB2
Family name: Serpin » Ov-serpin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.  
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867] silver  
  • IBARefGenome
GO biological process 
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAInterPro 2 GO
Negative regulation of endopeptidase activitydefinition[GO:0010951] silver  
  • IBARefGenome
Regulation of proteolysisdefinition[GO:0030162] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Amoebiasis  hsa05146+5055  
According to Reactome, this protein belongs to the following pathway:
Dissolution of Fibrin Clot  REACT_641  
 

Keywords

Biological process 
Plasminogen activation  definition   [KW-0617]
Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links