SERPINE1 - Plasminogen activator inhibitor 1 - human protein (Function)
 
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SERPINE1 »  Plasminogen activator inhibitor 1  (PAI)
 
Protein also known as:  Endothelial plasminogen activator inhibitor.
Gene name:  SERPINE1
Family name: Serpin
Entry whose protein(s) existence is based on evidence at protein level
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1 131 2
GENE REF ISO

Function

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Overview 
Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.  
1
  • CuratedUniProtKB
GO molecular function 
Protease bindingdefinition[GO:0002020]  
5
  • IPIUniProtKB
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Contributes to receptor bindingdefinition[GO:0005102]  
1
  • IPIBHF-UCL
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
2
  • IDABHF-UCL
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • IEPUniProtKB
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • IMPBHF-UCL
Chronological cell agingdefinition[GO:0001300]  
1
  • IEPBHF-UCL
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
1
  • IGIBHF-UCL
Negative regulation of blood coagulationdefinition[GO:0030195]  
1
  • ICBHF-UCL
Negative regulation of cell adhesion mediated by integrindefinition[GO:0033629]  
1
  • IDABHF-UCL
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IDABHF-UCL
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • IDABHF-UCL
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352]  
1
  • IMPBHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902042]  
1
  • IMPBHF-UCL
Negative regulation of fibrinolysisdefinition[GO:0051918]  
1
  • IDABHF-UCL
Negative regulation of plasminogen activationdefinition[GO:0010757]  
3
  • IMPBHF-UCL
Negative regulation of smooth muscle cell migrationdefinition[GO:0014912]  
1
  • IDABHF-UCL
Negative regulation of smooth muscle cell-matrix adhesiondefinition[GO:2000098]  
1
  • IDABHF-UCL
Negative regulation of vascular wound healingdefinition[GO:0061044]  
1
  • IGIBHF-UCL
Negative regulation of wound healingdefinition[GO:0061045]  
1
  • ICBHF-UCL
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IMPBHF-UCL
Positive regulation of blood coagulationdefinition[GO:0030194]  
1
  • IMPBHF-UCL
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • IGIBHF-UCL
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
1
  • IMPBHF-UCL
Positive regulation of leukotriene production involved in inflammatory responsedefinition[GO:0035491]  
1
  • IMPBHF-UCL
Positive regulation of monocyte chemotaxisdefinition[GO:0090026]  
1
  • IMPBHF-UCL
Positive regulation of receptor-mediated endocytosisdefinition[GO:0048260]  
1
  • IDABHF-UCL
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Regulation of receptor activitydefinition[GO:0010469]  
1
  • IDABHF-UCL
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chagas disease (American trypanosomiasis)  hsa05142+5054  
Complement and coagulation cascades  hsa04610+5054  
p53 signaling pathway  hsa04115+5054  
According to Reactome, this protein belongs to the following pathways:
BMAL1:CLOCK,NPAS2 activates circadian gene expression  REACT_111118  
Dissolution of Fibrin Clot  REACT_641  
ECM proteoglycans  REACT_163906  
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription  REACT_120734  
 

Keywords

Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links