MPO - Myeloperoxidase - human protein (Function)
 
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MPO »  Myeloperoxidase   [ EC 1.11.2.2 ]  (MPO)
 
Cleaved into:  84 kDa myeloperoxidase; 89 kDa myeloperoxidase; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain.
Gene name:  MPO
Family name: Peroxidase » XPO
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.  
1
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • PINC
Heme bindingdefinition[GO:0020037] silver  
1
  • InterPro 2 GO
Heparin bindingdefinition[GO:0008201]  
1
  • MGI
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Peroxidase activitydefinition[GO:0004601]  
3
  • CACAO
  • MGI
  • BHF-UCL
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Defense responsedefinition[GO:0006952]  
1
  • PINC
Defense response to fungusdefinition[GO:0050832] silver  
1
  • Ortholog Compara
Hydrogen peroxide catabolic processdefinition[GO:0042744]  
2
  • MGI
  • BHF-UCL
Hypochlorous acid biosynthetic processdefinition[GO:0002149] silver  
1
  • Ortholog Compara
Low-density lipoprotein particle remodelingdefinition[GO:0034374]  
1
  • BHF-UCL
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • PINC
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • BHF-UCL
Removal of superoxide radicalsdefinition[GO:0019430] silver  
1
  • Ortholog Compara
Respiratory burst involved in defense responsedefinition[GO:0002679] silver  
1
  • Ortholog Compara
Response to fooddefinition[GO:0032094] silver  
1
  • Ortholog Compara
Response to gold nanoparticledefinition[GO:1990268] silver  
1
  • Ortholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
1
  • Ortholog Compara
Response to oxidative stressdefinition[GO:0006979]  
1
  • UniProtKB
Response to yeastdefinition[GO:0001878] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
Cl(-) + H(2)O(2) HOCl + 2 H(2)O.  
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  • UniProtKB
EC 1.11.2.2: Cl(-) + H(2)O(2) + H(+) HClO + H(2)O.  
1
  • UniProtKB
It requires the following cofactors
 Ca(2+) : Binds 1 Ca(2+) ion per monomer.  
1
  • UniProtKB
 heme b : Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Phagosome  hsa04145+4353  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen peroxide  definition   [KW-0376]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Peroxidase  definition   [KW-0575]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Myeloperoxidase
GenomeRNAi: 4353
PRO: PR:P05164
Chemistry
GuidetoPHARMACOLOGY: 2789