MPO - Myeloperoxidase - human protein (Function)
 
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MPO »  Myeloperoxidase   [ EC 1.11.2.2 ]  (MPO)
 
Cleaved into:  84 kDa myeloperoxidase; 89 kDa myeloperoxidase; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain.
Gene name:  MPO
Family name: Peroxidase » XPO
Entry whose protein(s) existence is based on evidence at protein level
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1 290 3
GENE REF ISO

Function

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Overview 
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.  
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • TASPINC
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Heparin bindingdefinition[GO:0008201]  
1
  • IDAMGI
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Peroxidase activitydefinition[GO:0004601]  
2
  • IDAMGI
  • IDABHF-UCL
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Defense responsedefinition[GO:0006952]  
1
  • TASPINC
Defense response to fungusdefinition[GO:0050832] silver  
  • IEAOrtholog Compara
Hydrogen peroxide catabolic processdefinition[GO:0042744]  
2
  • IDAMGI
  • IDABHF-UCL
Hypochlorous acid biosynthetic processdefinition[GO:0002149] silver  
  • IEAOrtholog Compara
Low-density lipoprotein particle remodelingdefinition[GO:0034374]  
1
  • IDABHF-UCL
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • TASPINC
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
  • IEAOrtholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDABHF-UCL
Removal of superoxide radicalsdefinition[GO:0019430] silver  
  • IEAOrtholog Compara
Respiratory burst involved in defense responsedefinition[GO:0002679] silver  
  • IEAOrtholog Compara
Response to fooddefinition[GO:0032094] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to oxidative stressdefinition[GO:0006979]  
1
  • TASUniProtKB
Response to yeastdefinition[GO:0001878] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
Cl(-) + H(2)O(2) HOCl + 2 H(2)O.  
  • CuratedUniProtKB
EC 1.11.2.2: Cl(-) + H(2)O(2) + H(+) HClO + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 calcium ion per monomer.  
  • CuratedUniProtKB
Binds 1 heme B (iron-protoporphyrin IX) group covalently per monomer.  
  • CuratedUniProtKB
 
More information is available from:
  • PeroxiBase: 3315 [ HsMPO ]
Pathways 
According to KEGG, this protein belongs to the following pathway:
Phagosome  hsa04145+4353  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen peroxide  definition   [KW-0376]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Peroxidase  definition   [KW-0575]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Myeloperoxidase
GenomeRNAi: 4353
PRO: PR:P05164