CYP1A2 - Cytochrome P450 1A2 - human protein (Function)
 
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CYP1A2 »  Cytochrome P450 1A2   [ EC 1.14.14.1 ]
 
Protein also known as:  Cytochrome P450-P3.
Gene name:  CYP1A2
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 171 2
GENE REF ISO

Function

 show evidences
Overview 
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.  
1
  • CuratedUniProtKB
GO molecular function 
Aromatase activitydefinition[GO:0070330]  
  • IEAEC 2 GO
Caffeine oxidase activitydefinition[GO:0034875]  
1
  • IDABHF-UCL
Demethylase activitydefinition[GO:0032451]  
1
  • IDAUniProtKB
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Heme bindingdefinition[GO:0020037]  
1
  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Monooxygenase activitydefinition[GO:0004497]  
2
  • IDABHF-UCL
Oxidoreductase activitydefinition[GO:0016491]  
2
  • IDABHF-UCL
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygendefinition[GO:0016712]  
1
  • IMPUniProtKB
GO biological process 
Alkaloid metabolic processdefinition[GO:0009820]  
1
  • IDABHF-UCL
Cellular respirationdefinition[GO:0045333] silver  
  • IEAOrtholog Compara
Cellular response to cadmium iondefinition[GO:0071276] silver  
  • IEAOrtholog Compara
Dibenzo-p-dioxin metabolic processdefinition[GO:0018894] silver  
  • IEAOrtholog Compara
Drug catabolic processdefinition[GO:0042737]  
1
  • IMPBHF-UCL
Drug metabolic processdefinition[GO:0017144]  
2
  • IDABHF-UCL
Exogenous drug catabolic processdefinition[GO:0042738]  
1
  • IDABHF-UCL
Heterocycle metabolic processdefinition[GO:0046483]  
1
  • IDABHF-UCL
Hydrogen peroxide biosynthetic processdefinition[GO:0050665] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Monocarboxylic acid metabolic processdefinition[GO:0032787]  
1
  • IDABHF-UCL
Monoterpenoid metabolic processdefinition[GO:0016098]  
1
  • IDABHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
2
  • IDABHF-UCL
Oxidative deethylationdefinition[GO:0071615]  
1
  • IDABHF-UCL
Oxidative demethylationdefinition[GO:0070989]  
1
  • IDABHF-UCL
Porphyrin-containing compound metabolic processdefinition[GO:0006778] silver  
  • IEAOrtholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Regulation of gene expressiondefinition[GO:0010468] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Steroid catabolic processdefinition[GO:0006706]  
1
  • IMPBHF-UCL
Toxin biosynthetic processdefinition[GO:0009403]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.14.1: RH + reduced flavoprotein + O(2) ROH + oxidized flavoprotein + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Caffeine metabolism  hsa00232+1544  
Drug metabolism - cytochrome P450  hsa00982+1544  
Linoleic acid metabolism  hsa00591+1544  
Metabolic pathways  hsa01100+1544  
Metabolism of xenobiotics by cytochrome P450  hsa00980+1544  
Retinol metabolism  hsa00830+1544  
Tryptophan metabolism  hsa00380+1544  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 21 uM for 2-amino-3-methylimidazo[4,5-f]quinoline
KM 25 uM for phenacetin
KM 26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline
KM 71 uM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
KM 4 uM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole
KM 27 uM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P05177
Other
GeneWiki: CYP1A2
GenomeRNAi: 1544
PRO: PR:P05177