ALPL - Alkaline phosphatase, tissue-nonspecific isozyme - human protein (Function)
 
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ALPL »  Alkaline phosphatase, tissue-nonspecific isozyme   [ EC 3.1.3.1 ]  (TNSALP)
 
Protein also known as:  Alkaline phosphatase liver/bone/kidney isozyme.
Gene name:  ALPL
Family name: Alkaline phosphatase
Entry whose protein(s) existence is based on evidence at protein level
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1 155 3
GENE REF ISO

Function

 show evidences
Overview 
This isozyme may play a role in skeletal mineralization.  
1
  • UniProtKB
GO molecular function 
Alkaline phosphatase activitydefinition[GO:0004035]  
1
  • EC 2 GO
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Pyrophosphatase activitydefinition[GO:0016462]  
1
  • MGI
GO biological process 
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
1
  • Ortholog Compara
Cementum mineralizationdefinition[GO:0071529] silver  
1
  • Ortholog Compara
Dephosphorylationdefinition[GO:0016311] silver  
1
  • Ortholog Compara
Developmental process involved in reproductiondefinition[GO:0003006] silver  
1
  • Ortholog Compara
Endochondral ossificationdefinition[GO:0001958] silver  
1
  • Ortholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
1
  • UniProtKB
Response to antibioticdefinition[GO:0046677] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
Response to vitamin Ddefinition[GO:0033280]  
1
  • BHF-UCL
Skeletal system developmentdefinition[GO:0001501]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.1: A phosphate monoester + H(2)O an alcohol + phosphate.  
2
  • PROSITE-ProRule
  • UniProtKB
It requires the following cofactors
 Mg(2+) : Binds 1 Mg(2+) ion.  
1
  • UniProtKB
 Zn(2+) : Binds 2 Zn(2+) ions.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Folate biosynthesis  hsa00790+249  
Metabolic pathways  hsa01100+249  
 

Keywords

Biological process 
Biomineralization  definition   [KW-0091]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALPL
GenomeRNAi: 249
PRO: PR:P05186