ALPP - Alkaline phosphatase, placental type - human protein (Function)
 
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ALPP »  Alkaline phosphatase, placental type   [ EC 3.1.3.1 ]
 
Protein also known as:  Alkaline phosphatase Regan isozyme.
Gene name:  ALPP
Family name: Alkaline phosphatase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 57 1
GENE REF ISO

Function

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GO molecular function 
Alkaline phosphatase activitydefinition[GO:0004035]  
3
  • IDAUniProtKB
  • IDAMGI
Magnesium ion bindingdefinition[GO:0000287]  
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270]  
  • ISSOrtholog Curator
GO biological process 
Dephosphorylationdefinition[GO:0016311]  
3
  • IDAGOC
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.1: A phosphate monoester + H(2)O an alcohol + phosphate.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 magnesium ion.  
4
  • CuratedUniProtKB
Binds 2 zinc ions.  
4
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Folate biosynthesis  hsa00790+250  
Metabolic pathways  hsa01100+250  
Note 
In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links