FGF1 - Fibroblast growth factor 1 - human protein (Function)
 
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FGF1 »  Fibroblast growth factor 1  (FGF-1)
 
Protein also known as:  Acidic fibroblast growth factor (aFGF).
Gene name:  FGF1
Entry whose protein(s) existence is based on evidence at protein level
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1 130 2
GENE REF ISO

Function

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Overview 
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.  
3
  • CuratedUniProtKB
GO molecular function 
Fibroblast growth factor receptor bindingdefinition[GO:0005104]  
2
  • IPIMGI
Growth factor activitydefinition[GO:0008083]  
1
  • IDAUniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • IDAUniProtKB
Hsp70 protein bindingdefinition[GO:0030544] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
S100 protein bindingdefinition[GO:0044548]  
1
  • IPIUniProtKB
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • TASPINC
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Branch elongation involved in ureteric bud branchingdefinition[GO:0060681]  
1
  • IDAUniProtKB
Cellular response to heatdefinition[GO:0034605]  
1
  • IDAUniProtKB
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
4
  • IDAUniProtKB
  • IGIMGI
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Mesonephric epithelium developmentdefinition[GO:0072163]  
1
  • IDAUniProtKB
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Organ inductiondefinition[GO:0001759] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IDAUniProtKB
Positive regulation of cell divisiondefinition[GO:0051781]  
1
  • IDAUniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IGIMGI
Positive regulation of cholesterol biosynthetic processdefinition[GO:0045542]  
1
  • IDABHF-UCL
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of intracellular signal transductiondefinition[GO:1902533]  
1
  • IDABHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+2246  
Melanoma  hsa05218+2246  
Pathways in cancer  hsa05200+2246  
Regulation of actin cytoskeleton  hsa04810+2246  
According to Reactome, this protein belongs to the following pathways:
Activated point mutants of FGFR2  REACT_120863  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
FGFR1b ligand binding and activation  REACT_9400  
FGFR1c ligand binding and activation  REACT_9515  
FGFR2b ligand binding and activation  REACT_9416  
FGFR2c ligand binding and activation  REACT_9413  
FGFR3b ligand binding and activation  REACT_9508  
FGFR3c ligand binding and activation  REACT_9510  
FGFR4 ligand binding and activation  REACT_9452  
FRS2-mediated cascade  REACT_21247  
Negative regulation of FGFR signaling  REACT_111184  
Phospholipase C-mediated cascade  REACT_21310  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PIP3 activates AKT signaling  REACT_75829  
SHC-mediated cascade  REACT_21374  
Signaling by activated point mutants of FGFR1  REACT_121153  
Signaling by activated point mutants of FGFR3  REACT_121337  
Signaling by FGFR mutants  REACT_121398  
Signaling by FGFR3 mutants  REACT_121249  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FGF1
GenomeRNAi: 2246
PRO: PR:P05230