FGF1 - Fibroblast growth factor 1 - human protein (Function)
 
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FGF1 »  Fibroblast growth factor 1  (FGF-1)
 
Protein also known as:  Heparin-binding growth factor 1 (HBGF-1).
Gene name:  FGF1
Entry whose protein(s) existence is based on evidence at protein level
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1 141 2
GENE REF ISO

Function

 show evidences
Overview 
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.  
4
  • UniProtKB
GO molecular function 
Fibroblast growth factor receptor bindingdefinition[GO:0005104]  
2
  • MGI
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
S100 protein bindingdefinition[GO:0044548]  
1
  • UniProtKB
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • PINC
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB KW
Branch elongation involved in ureteric bud branchingdefinition[GO:0060681]  
1
  • UniProtKB
Cellular response to heatdefinition[GO:0034605]  
1
  • UniProtKB
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
4
  • UniProtKB
  • MGI
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Mesonephric epithelium developmentdefinition[GO:0072163]  
1
  • UniProtKB
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • PINC
Organ inductiondefinition[GO:0001759] silver  
1
  • Ortholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • UniProtKB
Positive regulation of cell divisiondefinition[GO:0051781]  
1
  • UniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • MGI
Positive regulation of cholesterol biosynthetic processdefinition[GO:0045542]  
1
  • BHF-UCL
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
1
  • Ortholog Compara
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • UniProtKB
Positive regulation of intracellular signal transductiondefinition[GO:1902533]  
1
  • BHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • BHF-UCL
Regulation of endothelial cell chemotaxis to fibroblast growth factordefinition[GO:2000544]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+2246  
Melanoma  hsa05218+2246  
Pathways in cancer  hsa05200+2246  
Regulation of actin cytoskeleton  hsa04810+2246  
According to Reactome, this protein belongs to the following pathways:
Activated point mutants of FGFR2  R-HSA-2033519  
Constitutive Signaling by Aberrant PI3K in Cancer  R-HSA-2219530  
FGFR1b ligand binding and activation  R-HSA-190370  
FGFR1c ligand binding and activation  R-HSA-190373  
FGFR2b ligand binding and activation  R-HSA-190377  
FGFR2c ligand binding and activation  R-HSA-190375  
FGFR3 mutant receptor activation  R-HSA-2033514  
FGFR3b ligand binding and activation  R-HSA-190371  
FGFR3c ligand binding and activation  R-HSA-190372  
FGFR4 ligand binding and activation  R-HSA-190322  
FRS-mediated FGFR1 signaling  R-HSA-5654693  
FRS-mediated FGFR2 signaling  R-HSA-5654700  
FRS-mediated FGFR3 signaling  R-HSA-5654706  
FRS-mediated FGFR4 signaling  R-HSA-5654712  
Negative regulation of FGFR1 signaling  R-HSA-5654726  
Negative regulation of FGFR2 signaling  R-HSA-5654727  
Negative regulation of FGFR3 signaling  R-HSA-5654732  
Negative regulation of FGFR4 signaling  R-HSA-5654733  
Phospholipase C-mediated cascade, FGFR2  R-HSA-5654221  
Phospholipase C-mediated cascade, FGFR3  R-HSA-5654227  
Phospholipase C-mediated cascade, FGFR4  R-HSA-5654228  
Phospholipase C-mediated cascade: FGFR1  R-HSA-5654219  
PI-3K cascade:FGFR1  R-HSA-5654689  
PI-3K cascade:FGFR2  R-HSA-5654695  
PI-3K cascade:FGFR3  R-HSA-5654710  
PI-3K cascade:FGFR4  R-HSA-5654720  
PI3K Cascade  R-HSA-109704  
PIP3 activates AKT signaling  R-HSA-1257604  
RAF/MAP kinase cascade  R-HSA-5673001  
SHC-mediated cascade:FGFR1  R-HSA-5654688  
SHC-mediated cascade:FGFR2  R-HSA-5654699  
SHC-mediated cascade:FGFR3  R-HSA-5654704  
SHC-mediated cascade:FGFR4  R-HSA-5654719  
Signaling by activated point mutants of FGFR1  R-HSA-1839122  
Signaling by activated point mutants of FGFR3  R-HSA-1839130  
Signaling by FGFR1 in disease  R-HSA-5655302  
Signaling by FGFR2 in disease  R-HSA-5655253  
Signaling by FGFR3 in disease  R-HSA-5655332  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FGF1
GenomeRNAi: 2246
PRO: PR:P05230