IL6 - Interleukin-6 - human protein (Function)
 
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IL6 »  Interleukin-6  (IL-6)
 
Protein also known as:  B-cell stimulatory factor 2 (BSF-2).
Gene name:  IL6
Family name: IL-6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 2119 1
GENE REF ISO

Function

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Overview 
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.  
1
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
3
  • BHF-UCL
Growth factor activitydefinition[GO:0008083]  
2
  • BHF-UCL
Contributes to interleukin-6 receptor bindingdefinition[GO:0005138]  
2
  • BHF-UCL
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • BHF-UCL
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Bone remodelingdefinition[GO:0046849] silver  
1
  • Ortholog Compara
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
1
  • Ortholog Compara
Cell growthdefinition[GO:0016049] silver  
1
  • Ortholog Compara
Cell redox homeostasisdefinition[GO:0045454] silver  
1
  • Ortholog Compara
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
1
  • Ortholog Compara
Cellular response to hydrogen peroxidedefinition[GO:0070301]  
1
  • BHF-UCL
Cellular response to interleukin-1definition[GO:0071347] silver  
1
  • Ortholog Compara
Cellular response to interleukin-6definition[GO:0071354]  
1
  • BHF-UCL
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • MGI
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
1
  • Ortholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
2
  • BHF-UCL
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
1
  • BHF-UCL
Defense response to Gram-positive bacteriumdefinition[GO:0050830]  
1
  • BHF-UCL
Defense response to protozoandefinition[GO:0042832] silver  
1
  • Ortholog Compara
Defense response to virusdefinition[GO:0051607]  
1
  • BHF-UCL
Endocrine pancreas developmentdefinition[GO:0031018]  
1
  • BHF-UCL
Epithelial cell proliferation involved in salivary gland morphogenesisdefinition[GO:0060664] silver  
1
  • Ortholog Compara
Glucagon secretiondefinition[GO:0070091]  
1
  • BHF-UCL
Glucose homeostasisdefinition[GO:0042593] silver  
1
  • Ortholog Compara
Hepatic immune responsedefinition[GO:0002384]  
2
  • BHF-UCL
Humoral immune responsedefinition[GO:0006959]  
1
  • BHF-UCL
Inflammatory responsedefinition[GO:0006954]  
1
  • BHF-UCL
Interleukin-6-mediated signaling pathwaydefinition[GO:0070102]  
1
  • BHF-UCL
Monocyte chemotaxisdefinition[GO:0002548]  
1
  • BHF-UCL
Muscle cell cellular homeostasisdefinition[GO:0046716] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of chemokine biosynthetic processdefinition[GO:0045079]  
1
  • Ortholog Curator
Negative regulation of collagen biosynthetic processdefinition[GO:0032966]  
1
  • BHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154] silver  
1
  • Ortholog Compara
Negative regulation of cytokine secretiondefinition[GO:0050710] silver  
1
  • Ortholog Compara
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • BHF-UCL
Negative regulation of gluconeogenesisdefinition[GO:0045721] silver  
1
  • Ortholog Compara
Negative regulation of hormone secretiondefinition[GO:0046888] silver  
1
  • Ortholog Compara
Negative regulation of lipid storagedefinition[GO:0010888]  
1
  • BHF-UCL
Negative regulation of muscle organ developmentdefinition[GO:0048635] silver  
1
  • Ortholog Compara
Negative regulation of neuron deathdefinition[GO:1901215] silver  
1
  • Ortholog Compara
Negative regulation of protein kinase activitydefinition[GO:0006469] silver  
1
  • Ortholog Compara
Neuron projection developmentdefinition[GO:0031175]  
1
  • BHF-UCL
Neutrophil apoptotic processdefinition[GO:0001781]  
1
  • UniProtKB
Neutrophil mediated immunitydefinition[GO:0002446]  
1
  • BHF-UCL
Platelet activationdefinition[GO:0030168]  
1
  • BHF-UCL
Positive regulation of acute inflammatory responsedefinition[GO:0002675]  
1
  • BHF-UCL
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Positive regulation of B cell activationdefinition[GO:0050871]  
1
  • BHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • BHF-UCL
Positive regulation of chemokine productiondefinition[GO:0032722]  
2
  • BHF-UCL
Positive regulation of DNA replicationdefinition[GO:0045740] silver  
1
  • Ortholog Compara
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
1
  • Ortholog Compara
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
1
  • Ortholog Compara
Positive regulation of immunoglobulin secretiondefinition[GO:0051024]  
1
  • BHF-UCL
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • BHF-UCL
Positive regulation of JAK-STAT cascadedefinition[GO:0046427]  
3
  • BHF-UCL
Positive regulation of leukocyte chemotaxisdefinition[GO:0002690]  
1
  • BHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410]  
2
  • BHF-UCL
  • MGI
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
1
  • Ortholog Compara
Not  Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • BHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429] silver  
1
  • Ortholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • BHF-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • MGI
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • MGI
Positive regulation of protein import into nucleus, translocationdefinition[GO:0033160] silver  
1
  • Ortholog Compara
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
1
  • Ortholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • BHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • BHF-UCL
Positive regulation of STAT protein import into nucleusdefinition[GO:2000366]  
1
  • BHF-UCL
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • BHF-UCL
Positive regulation of T-helper 2 cell differentiationdefinition[GO:0045630] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • BHF-UCL
  • MGI
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • BHF-UCL
Positive regulation of translationdefinition[GO:0045727]  
1
  • UniProtKB
Positive regulation of transmission of nerve impulsedefinition[GO:0051971] silver  
1
  • Ortholog Compara
Positive regulation of type B pancreatic cell apoptotic processdefinition[GO:2000676]  
1
  • BHF-UCL
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
1
  • BHF-UCL
Regulation of angiogenesisdefinition[GO:0045765]  
1
  • BHF-UCL
Regulation of cell shapedefinition[GO:0008360] silver  
1
  • Ortholog Compara
Regulation of circadian sleep/wake cycle, non-REM sleepdefinition[GO:0045188] silver  
1
  • Ortholog Compara
Regulation of vascular endothelial growth factor productiondefinition[GO:0010574]  
1
  • BHF-UCL
Response to amino aciddefinition[GO:0043200] silver  
1
  • Ortholog Compara
Response to antibioticdefinition[GO:0046677] silver  
1
  • Ortholog Compara
Response to auditory stimulusdefinition[GO:0010996] silver  
1
  • Ortholog Compara
Response to caffeinedefinition[GO:0031000] silver  
1
  • Ortholog Compara
Response to calcium iondefinition[GO:0051592] silver  
1
  • Ortholog Compara
Response to colddefinition[GO:0009409] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384]  
1
  • BHF-UCL
Response to heatdefinition[GO:0009408] silver  
1
  • Ortholog Compara
Response to insulindefinition[GO:0032868] silver  
1
  • Ortholog Compara
Response to nutrient levelsdefinition[GO:0031667] silver  
1
  • Ortholog Compara
Response to peptidoglycandefinition[GO:0032494]  
1
  • BHF-UCL
T-helper 17 cell lineage commitmentdefinition[GO:0072540]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+3569  
Amoebiasis  hsa05146+3569  
Chagas disease (American trypanosomiasis)  hsa05142+3569  
Cytokine-cytokine receptor interaction  hsa04060+3569  
Cytosolic DNA-sensing pathway  hsa04623+3569  
Hematopoietic cell lineage  hsa04640+3569  
Herpes simplex infection  hsa05168+3569  
HTLV-I infection  hsa05166+3569  
Influenza A  hsa05164+3569  
Intestinal immune network for IgA production  hsa04672+3569  
Jak-STAT signaling pathway  hsa04630+3569  
Legionellosis  hsa05134+3569  
Malaria  hsa05144+3569  
Measles  hsa05162+3569  
NOD-like receptor signaling pathway  hsa04621+3569  
Pertussis  hsa05133+3569  
Prion diseases  hsa05020+3569  
Salmonella infection  hsa05132+3569  
Toll-like receptor signaling pathway  hsa04620+3569  
Tuberculosis  hsa05152+3569  
According to Reactome, this protein belongs to the following pathways:
ERK1 activation  REACT_1391  
ERK2 activation  REACT_1183  
Interleukin-6 signaling  REACT_27307  
Senescence-Associated Secretory Phenotype (SASP)  REACT_169168  
 

Keywords

Biological process 
Acute phase  definition   [KW-0011]
Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Interleukin_6
GenomeRNAi: 3569
PRO: PR:P05231