IL6 - Interleukin-6 - human protein (Function)
 
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IL6 »  Interleukin-6  (IL-6)
 
Protein also known as:  B-cell stimulatory factor 2 (BSF-2).
Gene name:  IL6
Family name: IL-6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 1774 1
GENE REF ISO

Function

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Overview 
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
3
  • NASBHF-UCL
Growth factor activitydefinition[GO:0008083]  
2
  • IDABHF-UCL
Contributes to interleukin-6 receptor bindingdefinition[GO:0005138]  
2
  • IPIBHF-UCL
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • TASBHF-UCL
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Bone remodelingdefinition[GO:0046849] silver  
  • IEAOrtholog Compara
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
  • IEAOrtholog Compara
Cell growthdefinition[GO:0016049] silver  
  • IEAOrtholog Compara
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAOrtholog Compara
Cellular response to hydrogen peroxidedefinition[GO:0070301]  
1
  • IDABHF-UCL
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
2
  • IDABHF-UCL
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
1
  • IEPBHF-UCL
Defense response to Gram-positive bacteriumdefinition[GO:0050830]  
1
  • IEPBHF-UCL
Defense response to protozoandefinition[GO:0042832] silver  
  • IEAOrtholog Compara
Defense response to virusdefinition[GO:0051607]  
1
  • IDABHF-UCL
Endocrine pancreas developmentdefinition[GO:0031018]  
1
  • ISSBHF-UCL
Epithelial cell proliferation involved in salivary gland morphogenesisdefinition[GO:0060664] silver  
  • IEAOrtholog Compara
Glucagon secretiondefinition[GO:0070091]  
1
  • ISSBHF-UCL
Hepatic immune responsedefinition[GO:0002384]  
2
  • TASBHF-UCL
Humoral immune responsedefinition[GO:0006959]  
1
  • ICBHF-UCL
Inflammatory responsedefinition[GO:0006954]  
1
  • IDABHF-UCL
Interleukin-6-mediated signaling pathwaydefinition[GO:0070102]  
1
  • IDABHF-UCL
Monocyte chemotaxisdefinition[GO:0002548]  
1
  • ICBHF-UCL
Muscle cell cellular homeostasisdefinition[GO:0046716] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of chemokine biosynthetic processdefinition[GO:0045079]  
  • ISSOrtholog Curator
Negative regulation of collagen biosynthetic processdefinition[GO:0032966]  
1
  • IDABHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154] silver  
  • IEAOrtholog Compara
Negative regulation of cytokine secretiondefinition[GO:0050710] silver  
  • IEAOrtholog Compara
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • NASBHF-UCL
Negative regulation of gluconeogenesisdefinition[GO:0045721] silver  
  • IEAOrtholog Compara
Negative regulation of hormone secretiondefinition[GO:0046888] silver  
  • IEAOrtholog Compara
Negative regulation of lipid storagedefinition[GO:0010888]  
1
  • NASBHF-UCL
Negative regulation of muscle organ developmentdefinition[GO:0048635] silver  
  • IEAOrtholog Compara
Negative regulation of neuron deathdefinition[GO:1901215] silver  
  • IEAOrtholog Compara
Negative regulation of protein kinase activitydefinition[GO:0006469] silver  
  • IEAOrtholog Compara
Neuron projection developmentdefinition[GO:0031175]  
1
  • IMPBHF-UCL
Neutrophil apoptotic processdefinition[GO:0001781]  
1
  • IDAUniProtKB
Neutrophil mediated immunitydefinition[GO:0002446]  
1
  • ICBHF-UCL
Platelet activationdefinition[GO:0030168]  
1
  • TASBHF-UCL
Positive regulation of acute inflammatory responsedefinition[GO:0002675]  
1
  • IDABHF-UCL
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAUniProtKB
Positive regulation of B cell activationdefinition[GO:0050871]  
1
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IMPBHF-UCL
Positive regulation of chemokine productiondefinition[GO:0032722]  
2
  • IMPBHF-UCL
Positive regulation of DNA replicationdefinition[GO:0045740] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
  • IEAOrtholog Compara
Positive regulation of immunoglobulin secretiondefinition[GO:0051024]  
1
  • IDABHF-UCL
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • IDABHF-UCL
Positive regulation of JAK-STAT cascadedefinition[GO:0046427]  
3
  • IDABHF-UCL
Positive regulation of leukocyte chemotaxisdefinition[GO:0002690]  
1
  • ICBHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410]  
2
  • IDABHF-UCL
  • IDAMGI
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Not  Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IDABHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • TASBHF-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • IDAMGI
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDAMGI
Positive regulation of protein import into nucleus, translocationdefinition[GO:0033160] silver  
  • IEAOrtholog Compara
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDABHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • IDABHF-UCL
Positive regulation of STAT protein import into nucleusdefinition[GO:2000366]  
1
  • ICBHF-UCL
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IDABHF-UCL
Positive regulation of T-helper 2 cell differentiationdefinition[GO:0045630] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDABHF-UCL
  • IDAMGI
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDABHF-UCL
Positive regulation of translationdefinition[GO:0045727]  
1
  • IDAUniProtKB
Positive regulation of transmission of nerve impulsedefinition[GO:0051971] silver  
  • IEAOrtholog Compara
Positive regulation of type B pancreatic cell apoptotic processdefinition[GO:2000676]  
1
  • TASBHF-UCL
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
1
  • IDABHF-UCL
Regulation of angiogenesisdefinition[GO:0045765]  
1
  • ICBHF-UCL
Regulation of cell shapedefinition[GO:0008360] silver  
  • IEAOrtholog Compara
Regulation of circadian sleep/wake cycle, non-REM sleepdefinition[GO:0045188] silver  
  • IEAOrtholog Compara
Regulation of vascular endothelial growth factor productiondefinition[GO:0010574]  
1
  • IDABHF-UCL
Response to amino aciddefinition[GO:0043200] silver  
  • IEAOrtholog Compara
Response to antibioticdefinition[GO:0046677] silver  
  • IEAOrtholog Compara
Response to caffeinedefinition[GO:0031000] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384]  
1
  • IDABHF-UCL
Response to heatdefinition[GO:0009408] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to nutrient levelsdefinition[GO:0031667] silver  
  • IEAOrtholog Compara
Response to peptidoglycandefinition[GO:0032494]  
1
  • IEPBHF-UCL
T cell activationdefinition[GO:0042110] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+3569  
Amoebiasis  hsa05146+3569  
Chagas disease (American trypanosomiasis)  hsa05142+3569  
Cytokine-cytokine receptor interaction  hsa04060+3569  
Cytosolic DNA-sensing pathway  hsa04623+3569  
Hematopoietic cell lineage  hsa04640+3569  
Herpes simplex infection  hsa05168+3569  
HTLV-I infection  hsa05166+3569  
Influenza A  hsa05164+3569  
Intestinal immune network for IgA production  hsa04672+3569  
Jak-STAT signaling pathway  hsa04630+3569  
Legionellosis  hsa05134+3569  
Malaria  hsa05144+3569  
Measles  hsa05162+3569  
NOD-like receptor signaling pathway  hsa04621+3569  
Pertussis  hsa05133+3569  
Prion diseases  hsa05020+3569  
Salmonella infection  hsa05132+3569  
Toll-like receptor signaling pathway  hsa04620+3569  
Tuberculosis  hsa05152+3569  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Immune System  REACT_6900  
 

Keywords

Biological process 
Acute phase  definition   [KW-0011]
Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Interleukin_6
GenomeRNAi: 3569
PRO: PR:P05231