IL6 - Interleukin-6 - human protein (Function)
 
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IL6 »  Interleukin-6  (IL-6)
 
Protein also known as:  B-cell stimulatory factor 2 (BSF-2).
Gene name:  IL6
Family name: IL-6
Entry whose protein(s) existence is based on evidence at protein level
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1 1867 1
GENE REF ISO

Function

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Overview 
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
3
  • NASBHF-UCL
Growth factor activitydefinition[GO:0008083]  
2
  • IDABHF-UCL
Contributes to interleukin-6 receptor bindingdefinition[GO:0005138]  
2
  • IPIBHF-UCL
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • TASBHF-UCL
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Bone remodelingdefinition[GO:0046849] silver  
  • IEAOrtholog Compara
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
  • IEAOrtholog Compara
Cell growthdefinition[GO:0016049] silver  
  • IEAOrtholog Compara
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAOrtholog Compara
Cellular response to hydrogen peroxidedefinition[GO:0070301]  
1
  • IDABHF-UCL
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • IMPMGI
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
2
  • IDABHF-UCL
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
1
  • IEPBHF-UCL
Defense response to Gram-positive bacteriumdefinition[GO:0050830]  
1
  • IEPBHF-UCL
Defense response to protozoandefinition[GO:0042832] silver  
  • IEAOrtholog Compara
Defense response to virusdefinition[GO:0051607]  
1
  • IDABHF-UCL
Endocrine pancreas developmentdefinition[GO:0031018]  
1
  • ISSBHF-UCL
Epithelial cell proliferation involved in salivary gland morphogenesisdefinition[GO:0060664] silver  
  • IEAOrtholog Compara
Glucagon secretiondefinition[GO:0070091]  
1
  • ISSBHF-UCL
Hepatic immune responsedefinition[GO:0002384]  
2
  • TASBHF-UCL
Humoral immune responsedefinition[GO:0006959]  
1
  • ICBHF-UCL
Inflammatory responsedefinition[GO:0006954]  
1
  • IDABHF-UCL
Interleukin-6-mediated signaling pathwaydefinition[GO:0070102]  
1
  • IDABHF-UCL
Monocyte chemotaxisdefinition[GO:0002548]  
1
  • ICBHF-UCL
Muscle cell cellular homeostasisdefinition[GO:0046716] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of chemokine biosynthetic processdefinition[GO:0045079]  
  • ISSOrtholog Curator
Negative regulation of collagen biosynthetic processdefinition[GO:0032966]  
1
  • IDABHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154] silver  
  • IEAOrtholog Compara
Negative regulation of cytokine secretiondefinition[GO:0050710] silver  
  • IEAOrtholog Compara
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • NASBHF-UCL
Negative regulation of gluconeogenesisdefinition[GO:0045721] silver  
  • IEAOrtholog Compara
Negative regulation of hormone secretiondefinition[GO:0046888] silver  
  • IEAOrtholog Compara
Negative regulation of lipid storagedefinition[GO:0010888]  
1
  • NASBHF-UCL
Negative regulation of muscle organ developmentdefinition[GO:0048635] silver  
  • IEAOrtholog Compara
Negative regulation of neuron deathdefinition[GO:1901215] silver  
  • IEAOrtholog Compara
Negative regulation of protein kinase activitydefinition[GO:0006469] silver  
  • IEAOrtholog Compara
Neuron projection developmentdefinition[GO:0031175]  
1
  • IMPBHF-UCL
Neutrophil apoptotic processdefinition[GO:0001781]  
1
  • IDAUniProtKB
Neutrophil mediated immunitydefinition[GO:0002446]  
1
  • ICBHF-UCL
Platelet activationdefinition[GO:0030168]  
1
  • TASBHF-UCL
Positive regulation of acute inflammatory responsedefinition[GO:0002675]  
1
  • IDABHF-UCL
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAUniProtKB
Positive regulation of B cell activationdefinition[GO:0050871]  
1
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IMPBHF-UCL
Positive regulation of chemokine productiondefinition[GO:0032722]  
2
  • IMPBHF-UCL
Positive regulation of DNA replicationdefinition[GO:0045740] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
  • IEAOrtholog Compara
Positive regulation of immunoglobulin secretiondefinition[GO:0051024]  
1
  • IDABHF-UCL
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • IDABHF-UCL
Positive regulation of JAK-STAT cascadedefinition[GO:0046427]  
3
  • IDABHF-UCL
Positive regulation of leukocyte chemotaxisdefinition[GO:0002690]  
1
  • ICBHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410]  
2
  • IDABHF-UCL
  • IDAMGI
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Not  Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IDABHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • TASBHF-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • IDAMGI
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDAMGI
Positive regulation of protein import into nucleus, translocationdefinition[GO:0033160] silver  
  • IEAOrtholog Compara
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDABHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • IDABHF-UCL
Positive regulation of STAT protein import into nucleusdefinition[GO:2000366]  
1
  • ICBHF-UCL
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IDABHF-UCL
Positive regulation of T-helper 2 cell differentiationdefinition[GO:0045630] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDABHF-UCL
  • IDAMGI
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDABHF-UCL
Positive regulation of translationdefinition[GO:0045727]  
1
  • IDAUniProtKB
Positive regulation of transmission of nerve impulsedefinition[GO:0051971] silver  
  • IEAOrtholog Compara
Positive regulation of type B pancreatic cell apoptotic processdefinition[GO:2000676]  
1
  • TASBHF-UCL
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
1
  • IDABHF-UCL
Regulation of angiogenesisdefinition[GO:0045765]  
1
  • ICBHF-UCL
Regulation of cell shapedefinition[GO:0008360] silver  
  • IEAOrtholog Compara
Regulation of circadian sleep/wake cycle, non-REM sleepdefinition[GO:0045188] silver  
  • IEAOrtholog Compara
Regulation of vascular endothelial growth factor productiondefinition[GO:0010574]  
1
  • IDABHF-UCL
Response to amino aciddefinition[GO:0043200] silver  
  • IEAOrtholog Compara
Response to antibioticdefinition[GO:0046677] silver  
  • IEAOrtholog Compara
Response to caffeinedefinition[GO:0031000] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384]  
1
  • IDABHF-UCL
Response to heatdefinition[GO:0009408] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to nutrient levelsdefinition[GO:0031667] silver  
  • IEAOrtholog Compara
Response to peptidoglycandefinition[GO:0032494]  
1
  • IEPBHF-UCL
T-helper 17 cell lineage commitmentdefinition[GO:0072540]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+3569  
Amoebiasis  hsa05146+3569  
Chagas disease (American trypanosomiasis)  hsa05142+3569  
Cytokine-cytokine receptor interaction  hsa04060+3569  
Cytosolic DNA-sensing pathway  hsa04623+3569  
Hematopoietic cell lineage  hsa04640+3569  
Herpes simplex infection  hsa05168+3569  
HTLV-I infection  hsa05166+3569  
Influenza A  hsa05164+3569  
Intestinal immune network for IgA production  hsa04672+3569  
Jak-STAT signaling pathway  hsa04630+3569  
Legionellosis  hsa05134+3569  
Malaria  hsa05144+3569  
Measles  hsa05162+3569  
NOD-like receptor signaling pathway  hsa04621+3569  
Pertussis  hsa05133+3569  
Prion diseases  hsa05020+3569  
Salmonella infection  hsa05132+3569  
Toll-like receptor signaling pathway  hsa04620+3569  
Tuberculosis  hsa05152+3569  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Immune System  REACT_6900  
 

Keywords

Biological process 
Acute phase  definition   [KW-0011]
Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Interleukin_6
GenomeRNAi: 3569
PRO: PR:P05231