EDN1 - Endothelin-1 - human protein (Function)
 
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EDN1 »  Endothelin-1
 
Protein also known as:  Preproendothelin-1 (PPET1). Cleaved into:  Big endothelin-1; Endothelin-1.
Gene name:  EDN1
Family name: Endothelin/sarafotoxin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 497 1
GENE REF ISO

Function

 show evidences
Overview 
Endothelins are endothelium-derived vasoconstrictor peptides.  
1
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • BHF-UCL
Endothelin A receptor bindingdefinition[GO:0031707]  
1
  • BHF-UCL
Endothelin B receptor bindingdefinition[GO:0031708]  
1
  • BHF-UCL
Hormone activitydefinition[GO:0005179]  
2
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Artery smooth muscle contractiondefinition[GO:0014824]  
2
  • BHF-UCL
Body fluid secretiondefinition[GO:0007589] silver  
1
  • Ortholog Compara
Calcium-mediated signalingdefinition[GO:0019722]  
2
  • BHF-UCL
Cartilage developmentdefinition[GO:0051216] silver  
1
  • Ortholog Compara
Cell growthdefinition[GO:0016049] silver  
1
  • Ortholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • BHF-UCL
Cell-cell signalingdefinition[GO:0007267]  
1
  • BHF-UCL
Cellular response to calcium iondefinition[GO:0071277] silver  
1
  • Ortholog Compara
Cellular response to drugdefinition[GO:0035690] silver  
1
  • Ortholog Compara
Cellular response to fatty aciddefinition[GO:0071398] silver  
1
  • Ortholog Compara
Cellular response to glucocorticoid stimulusdefinition[GO:0071385] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
Cellular response to interferon-gammadefinition[GO:0071346] silver  
1
  • Ortholog Compara
Cellular response to interleukin-1definition[GO:0071347] silver  
1
  • Ortholog Compara
Cellular response to mineralocorticoid stimulusdefinition[GO:0071389] silver  
1
  • Ortholog Compara
Cellular response to peptide hormone stimulusdefinition[GO:0071375] silver  
1
  • Ortholog Compara
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560] silver  
1
  • Ortholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
1
  • Ortholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953] silver  
1
  • Ortholog Compara
Epithelial fluid transportdefinition[GO:0042045] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • BHF-UCL
Glucose transportdefinition[GO:0015758] silver  
1
  • Ortholog Compara
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Histamine secretiondefinition[GO:0001821] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Inositol phosphate-mediated signalingdefinition[GO:0048016]  
1
  • BHF-UCL
Leukocyte activationdefinition[GO:0045321]  
1
  • BHF-UCL
Maternal process involved in parturitiondefinition[GO:0060137] silver  
1
  • Ortholog Compara
Membrane depolarizationdefinition[GO:0051899] silver  
1
  • Ortholog Compara
Middle ear morphogenesisdefinition[GO:0042474] silver  
1
  • Ortholog Compara
Multicellular organismal agingdefinition[GO:0010259] silver  
1
  • Ortholog Compara
Negative regulation of blood coagulationdefinition[GO:0030195]  
1
  • BHF-UCL
Negative regulation of cAMP biosynthetic processdefinition[GO:0030818] silver  
1
  • Ortholog Compara
Negative regulation of cellular protein metabolic processdefinition[GO:0032269]  
1
  • BHF-UCL
Negative regulation of hormone secretiondefinition[GO:0046888] silver  
1
  • Ortholog Compara
Negative regulation of nitric-oxide synthase biosynthetic processdefinition[GO:0051771]  
1
  • BHF-UCL
Negative regulation of smooth muscle cell apoptotic processdefinition[GO:0034392] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • BHF-UCL
Neural crest cell developmentdefinition[GO:0014032] silver  
1
  • Ortholog Compara
Not  Neutrophil chemotaxisdefinition[GO:0030593]  
1
  • BHF-UCL
Nitric oxide transportdefinition[GO:0030185]  
1
  • BHF-UCL
Patterning of blood vesselsdefinition[GO:0001569] silver  
1
  • Ortholog Compara
Peptide hormone secretiondefinition[GO:0030072]  
1
  • BHF-UCL
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • BHF-UCL
Phospholipase D-activating G-protein coupled receptor signaling pathwaydefinition[GO:0031583] silver  
1
  • Ortholog Compara
Positive regulation of cardiac muscle hypertrophydefinition[GO:0010613]  
1
  • BHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • BHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • BHF-UCL
Positive regulation of cell sizedefinition[GO:0045793]  
1
  • BHF-UCL
Positive regulation of chemokine-mediated signaling pathwaydefinition[GO:0070101]  
1
  • BHF-UCL
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • BHF-UCL
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482] silver  
1
  • Ortholog Compara
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • BHF-UCL
Positive regulation of heart ratedefinition[GO:0010460]  
1
  • BHF-UCL
Positive regulation of hormone secretiondefinition[GO:0046887]  
1
  • BHF-UCL
Positive regulation of JUN kinase activitydefinition[GO:0043507]  
1
  • BHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
2
  • BHF-UCL
Positive regulation of mitosisdefinition[GO:0045840]  
1
  • BHF-UCL
Positive regulation of neutrophil chemotaxisdefinition[GO:0090023] silver  
1
  • Ortholog Compara
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • BHF-UCL
Positive regulation of odontogenesisdefinition[GO:0042482] silver  
1
  • Ortholog Compara
Positive regulation of prostaglandin secretiondefinition[GO:0032308] silver  
1
  • Ortholog Compara
Positive regulation of prostaglandin-endoperoxide synthase activitydefinition[GO:0060585]  
1
  • BHF-UCL
Positive regulation of receptor biosynthetic processdefinition[GO:0010870]  
1
  • BHF-UCL
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
1
  • Ortholog Compara
Positive regulation of sarcomere organizationdefinition[GO:0060298]  
1
  • BHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • BHF-UCL
Positive regulation of smooth muscle contractiondefinition[GO:0045987] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Positive regulation of urine volumedefinition[GO:0035810] silver  
1
  • Ortholog Compara
Prostaglandin biosynthetic processdefinition[GO:0001516]  
1
  • BHF-UCL
Protein kinase C deactivationdefinition[GO:0042313]  
1
  • BHF-UCL
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
1
  • Ortholog Compara
Regulation of pHdefinition[GO:0006885] silver  
1
  • Ortholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
1
  • Ortholog Compara
Regulation of systemic arterial blood pressure by endothelindefinition[GO:0003100]  
1
  • BHF-UCL
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
1
  • InterPro 2 GO
Respiratory gaseous exchangedefinition[GO:0007585] silver  
1
  • Ortholog Compara
Response to activitydefinition[GO:0014823] silver  
1
  • Ortholog Compara
Response to amino aciddefinition[GO:0043200] silver  
1
  • Ortholog Compara
Response to dexamethasonedefinition[GO:0071548] silver  
1
  • Ortholog Compara
Response to leptindefinition[GO:0044321] silver  
1
  • Ortholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
Response to muscle stretchdefinition[GO:0035994] silver  
1
  • Ortholog Compara
Response to nicotinedefinition[GO:0035094] silver  
1
  • Ortholog Compara
Response to ozonedefinition[GO:0010193] silver  
1
  • Ortholog Compara
Response to prostaglandin Fdefinition[GO:0034696] silver  
1
  • Ortholog Compara
Response to saltdefinition[GO:1902074] silver  
1
  • Ortholog Compara
Response to testosteronedefinition[GO:0033574] silver  
1
  • Ortholog Compara
Rhythmic excitationdefinition[GO:0043179] silver  
1
  • Ortholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
1
  • Ortholog Compara
Superoxide anion generationdefinition[GO:0042554] silver  
1
  • Ortholog Compara
Vasoconstrictiondefinition[GO:0042310]  
2
  • BHF-UCL
Vein smooth muscle contractiondefinition[GO:0014826]  
1
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Melanogenesis  hsa04916+1906  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
Vasoactive  definition   [KW-0838]
Vasoconstrictor  definition   [KW-0839]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Endothelin_1
GenomeRNAi: 1906
PRO: PR:P05305