EDN1 - Endothelin-1 - human protein (Function)
 
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EDN1 »  Endothelin-1
 
Protein also known as:  Preproendothelin-1 (PPET1). Cleaved into:  Big endothelin-1; Endothelin-1.
Gene name:  EDN1
Family name: Endothelin/sarafotoxin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 468 1
GENE REF ISO

Function

 show evidences
Overview 
Endothelins are endothelium-derived vasoconstrictor peptides.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • IDABHF-UCL
Endothelin A receptor bindingdefinition[GO:0031707]  
1
  • IDABHF-UCL
Endothelin B receptor bindingdefinition[GO:0031708]  
1
  • IDABHF-UCL
Hormone activitydefinition[GO:0005179]  
2
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Artery smooth muscle contractiondefinition[GO:0014824]  
2
  • IDABHF-UCL
Body fluid secretiondefinition[GO:0007589] silver  
  • IEAOrtholog Compara
Calcium-mediated signalingdefinition[GO:0019722]  
2
  • IDABHF-UCL
Cartilage developmentdefinition[GO:0051216] silver  
  • IEAOrtholog Compara
Cell growthdefinition[GO:0016049] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • IDABHF-UCL
Cell-cell signalingdefinition[GO:0007267]  
1
  • IDABHF-UCL
Cellular response to interleukin-1definition[GO:0071347] silver  
  • IEAOrtholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
  • IEAOrtholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953] silver  
  • IEAOrtholog Compara
Epithelial fluid transportdefinition[GO:0042045] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDABHF-UCL
Glucose transportdefinition[GO:0015758] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Histamine secretiondefinition[GO:0001821] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Inositol phosphate-mediated signalingdefinition[GO:0048016]  
1
  • IDABHF-UCL
Leukocyte activationdefinition[GO:0045321]  
1
  • TASBHF-UCL
Maternal process involved in parturitiondefinition[GO:0060137] silver  
  • IEAOrtholog Compara
Membrane depolarizationdefinition[GO:0051899] silver  
  • IEAOrtholog Compara
Middle ear morphogenesisdefinition[GO:0042474] silver  
  • IEAOrtholog Compara
Multicellular organismal agingdefinition[GO:0010259] silver  
  • IEAOrtholog Compara
Negative regulation of blood coagulationdefinition[GO:0030195]  
1
  • TASBHF-UCL
Negative regulation of cAMP biosynthetic processdefinition[GO:0030818] silver  
  • IEAOrtholog Compara
Negative regulation of cellular protein metabolic processdefinition[GO:0032269]  
1
  • IDABHF-UCL
Negative regulation of hormone secretiondefinition[GO:0046888] silver  
  • IEAOrtholog Compara
Negative regulation of nitric-oxide synthase biosynthetic processdefinition[GO:0051771]  
1
  • IDABHF-UCL
Negative regulation of smooth muscle cell apoptotic processdefinition[GO:0034392] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
Neural crest cell developmentdefinition[GO:0014032] silver  
  • IEAOrtholog Compara
Not  Neutrophil chemotaxisdefinition[GO:0030593]  
1
  • IDABHF-UCL
Nitric oxide transportdefinition[GO:0030185]  
1
  • IDABHF-UCL
Patterning of blood vesselsdefinition[GO:0001569] silver  
  • IEAOrtholog Compara
Peptide hormone secretiondefinition[GO:0030072]  
1
  • IDABHF-UCL
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • IDABHF-UCL
Phospholipase D-activating G-protein coupled receptor signaling pathwaydefinition[GO:0031583] silver  
  • IEAOrtholog Compara
Positive regulation of cardiac muscle hypertrophydefinition[GO:0010613]  
1
  • IDABHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IDABHF-UCL
Positive regulation of cell sizedefinition[GO:0045793]  
1
  • IDABHF-UCL
Positive regulation of chemokine-mediated signaling pathwaydefinition[GO:0070101]  
1
  • ICBHF-UCL
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDABHF-UCL
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • TASBHF-UCL
Positive regulation of heart ratedefinition[GO:0010460]  
1
  • IDABHF-UCL
Positive regulation of hormone secretiondefinition[GO:0046887]  
1
  • IDABHF-UCL
Positive regulation of JUN kinase activitydefinition[GO:0043507]  
1
  • IDABHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
2
  • IDABHF-UCL
Positive regulation of mitosisdefinition[GO:0045840]  
1
  • IDABHF-UCL
Positive regulation of neutrophil chemotaxisdefinition[GO:0090023] silver  
  • IEAOrtholog Compara
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • TASBHF-UCL
Positive regulation of odontogenesisdefinition[GO:0042482] silver  
  • IEAOrtholog Compara
Positive regulation of prostaglandin-endoperoxide synthase activitydefinition[GO:0060585]  
1
  • IMPBHF-UCL
Positive regulation of receptor biosynthetic processdefinition[GO:0010870]  
1
  • IDABHF-UCL
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
  • IEAOrtholog Compara
Positive regulation of sarcomere organizationdefinition[GO:0060298]  
1
  • IMPBHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • IDABHF-UCL
Positive regulation of smooth muscle contractiondefinition[GO:0045987] silver  
  • IEAOrtholog Compara
Positive regulation of urine volumedefinition[GO:0035810] silver  
  • IEAOrtholog Compara
Prostaglandin biosynthetic processdefinition[GO:0001516]  
1
  • IDABHF-UCL
Protein kinase C deactivationdefinition[GO:0042313]  
1
  • IDABHF-UCL
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
  • IEAOrtholog Compara
Regulation of pHdefinition[GO:0006885] silver  
  • IEAOrtholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
  • IEAOrtholog Compara
Regulation of systemic arterial blood pressure by endothelindefinition[GO:0003100]  
1
  • IDABHF-UCL
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
  • IEAInterPro 2 GO
Respiratory gaseous exchangedefinition[GO:0007585] silver  
  • IEAOrtholog Compara
Response to amino aciddefinition[GO:0043200] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to nicotinedefinition[GO:0035094] silver  
  • IEAOrtholog Compara
Response to testosteronedefinition[GO:0033574] silver  
  • IEAOrtholog Compara
Rhythmic excitationdefinition[GO:0043179] silver  
  • IEAOrtholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Superoxide anion generationdefinition[GO:0042554] silver  
  • IEAOrtholog Compara
Vasoconstrictiondefinition[GO:0042310]  
2
  • IDABHF-UCL
Vein smooth muscle contractiondefinition[GO:0014826]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Melanogenesis  hsa04916+1906  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Vasoactive  definition   [KW-0838]
Vasoconstrictor  definition   [KW-0839]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Endothelin_1
GenomeRNAi: 1906
PRO: PR:P05305