ICAM1 - Intercellular adhesion molecule 1 - human protein (Function)
 
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ICAM1 »  Intercellular adhesion molecule 1  (ICAM-1)
 
Protein also known as:  Major group rhinovirus receptor; CD antigen CD54.
Gene name:  ICAM1
Family name: Immunoglobulin » ICAM
Entry whose protein(s) existence is based on evidence at protein level
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1 674 1
GENE REF ISO

Function

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Overview 
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.  
4
  • CuratedUniProtKB
GO molecular function 
Integrin bindingdefinition[GO:0005178]  
2
  • IDAMGI
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
Virus receptor activitydefinition[GO:0001618]  
  • IEAUniProtKB KW
GO biological process 
Adhesion to hostdefinition[GO:0044406]  
1
  • IDABHF-UCL
Cell adhesiondefinition[GO:0007155]  
1
  • IDABHF-UCL
Cell adhesion mediated by integrindefinition[GO:0033627] silver  
  • IEAOrtholog Compara
Cell agingdefinition[GO:0007569] silver  
  • IEAOrtholog Compara
Cellular response to alkaloiddefinition[GO:0071312] silver  
  • IEAOrtholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
  • IEAOrtholog Compara
Cellular response to interleukin-1definition[GO:0071347] silver  
  • IEAOrtholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Cellular response to nutrient levelsdefinition[GO:0031669] silver  
  • IEAOrtholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
  • IEAOrtholog Compara
Establishment of endothelial barrierdefinition[GO:0061028]  
1
  • IGIUniProtKB
Heterophilic cell-cell adhesiondefinition[GO:0007157]  
1
  • TASBHF-UCL
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
1
  • IMPBHF-UCL
Leukocyte migrationdefinition[GO:0050900]  
1
  • IEPBHF-UCL
Membrane to membrane dockingdefinition[GO:0022614]  
1
  • IEPBHF-UCL
Negative regulation of calcium ion transportdefinition[GO:0051926] silver  
  • IEAOrtholog Compara
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352]  
1
  • IDABHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902042]  
1
  • IDABHF-UCL
Ovarian follicle developmentdefinition[GO:0001541] silver  
  • IEAOrtholog Compara
Positive regulation of actin filament polymerizationdefinition[GO:0030838] silver  
  • IEAOrtholog Compara
Positive regulation of cellular extravasationdefinition[GO:0002693]  
1
  • IMPBHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IMPBHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092] silver  
  • IEAOrtholog Compara
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429] silver  
  • IEAOrtholog Compara
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731] silver  
  • IEAOrtholog Compara
Positive regulation of Rho GTPase activitydefinition[GO:0032321] silver  
  • IEAOrtholog Compara
Positive regulation of vasoconstrictiondefinition[GO:0045907] silver  
  • IEAOrtholog Compara
Receptor-mediated virion attachment to host celldefinition[GO:0046813]  
1
  • IDABHF-UCL
Regulation of cell adhesiondefinition[GO:0030155] silver  
  • IEAOrtholog Compara
Regulation of cell shapedefinition[GO:0008360] silver  
  • IEAOrtholog Compara
Regulation of leukocyte mediated cytotoxicitydefinition[GO:0001910]  
1
  • TASBHF-UCL
Response to amino aciddefinition[GO:0043200] silver  
  • IEAOrtholog Compara
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
Response to copper iondefinition[GO:0046688] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to gonadotropindefinition[GO:0034698] silver  
  • IEAOrtholog Compara
Response to ionizing radiationdefinition[GO:0010212] silver  
  • IEAOrtholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Response to sulfur dioxidedefinition[GO:0010477] silver  
  • IEAOrtholog Compara
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting celldefinition[GO:0002291]  
1
  • IMPBHF-UCL
T cell antigen processing and presentationdefinition[GO:0002457] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+3383  
Cell adhesion molecules (CAMs)  hsa04514+3383  
HTLV-I infection  hsa05166+3383  
Influenza A  hsa05164+3383  
Leukocyte transendothelial migration  hsa04670+3383  
Malaria  hsa05144+3383  
Natural killer cell mediated cytotoxicity  hsa04650+3383  
Rheumatoid arthritis  hsa05323+3383  
Staphylococcus aureus infection  hsa05150+3383  
Viral myocarditis  hsa05416+3383  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Immune System  REACT_6900  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Host cell receptor for virus entry  definition   [KW-1183]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P05362
Other
GeneWiki: ICAM-1
GenomeRNAi: 3383
PRO: PR:P05362