JUN - Transcription factor AP-1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
JUN »  Transcription factor AP-1
 
Protein also known as:  V-jun avian sarcoma virus 17 oncogene homolog.
Gene name:  JUN
Family name: bZIP » Jun
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 549 1
GENE REF ISO

Function

 show evidences
Overview 
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.  
2
  • CuratedUniProtKB
GO molecular function 
cAMP response element bindingdefinition[GO:0035497]  
1
  • IDABHF-UCL
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
HMG box domain bindingdefinition[GO:0071837] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
21
  • IPIIntAct
  • IPIUniProtKB
R-SMAD bindingdefinition[GO:0070412]  
1
  • IPIBHF-UCL
Rho GTPase activator activitydefinition[GO:0005100]  
1
  • IDAUniProtKB
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • IDABHF-UCL
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
2
  • ICBHF-UCL
  • IDAUniProtKB
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001190]  
1
  • ICBHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDABHF-UCL
Transcription coactivator activitydefinition[GO:0003713]  
1
  • IDAUniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
2
  • IDAUniProtKB
  • IDABHF-UCL
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Axon regenerationdefinition[GO:0031103] silver  
  • IEAOrtholog Compara
Cellular response to calcium iondefinition[GO:0071277] silver  
  • IEAOrtholog Compara
Cellular response to potassium ion starvationdefinition[GO:0051365] silver  
  • IEAOrtholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
  • IEAOrtholog Compara
Leading edge cell differentiationdefinition[GO:0035026] silver  
  • IEAOrtholog Compara
Learningdefinition[GO:0007612] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Membrane depolarizationdefinition[GO:0051899] silver  
  • IEAOrtholog Compara
Microglial cell activationdefinition[GO:0001774] silver  
  • IEAOrtholog Compara
Monocyte differentiationdefinition[GO:0030224] silver  
  • IEAOrtholog Compara
Negative regulation by host of viral transcriptiondefinition[GO:0043922]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of DNA bindingdefinition[GO:0043392]  
1
  • IDAUniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of protein autophosphorylationdefinition[GO:0031953] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Outflow tract morphogenesisdefinition[GO:0003151] silver  
  • IEAOrtholog Compara
Positive regulation by host of viral transcriptiondefinition[GO:0043923]  
1
  • IDAUniProtKB
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IDAGOC
Positive regulation of DNA replicationdefinition[GO:0045740] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell proliferationdefinition[GO:0001938] silver  
  • IEAOrtholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146] silver  
  • IEAOrtholog Compara
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • IDAGOC
Positive regulation of monocyte differentiationdefinition[GO:0045657] silver  
  • IEAOrtholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Positive regulation of Ras GTPase activitydefinition[GO:0032320]  
1
  • IDAGOC
Positive regulation of Rho GTPase activitydefinition[GO:0032321]  
1
  • IDAGOC
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • ICBHF-UCL
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • IDAGOC
Regulation of cell cycledefinition[GO:0051726] silver  
  • IEAOrtholog Compara
Release of cytochrome c from mitochondriadefinition[GO:0001836] silver  
  • IEAOrtholog Compara
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to cytokinedefinition[GO:0034097] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to radiationdefinition[GO:0009314] silver  
  • IEAOrtholog Compara
SMAD protein import into nucleusdefinition[GO:0007184]  
1
  • IDABHF-UCL
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • IDABHF-UCL
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+3725  
Chagas disease (American trypanosomiasis)  hsa05142+3725  
Colorectal cancer  hsa05210+3725  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+3725  
ErbB signaling pathway  hsa04012+3725  
Focal adhesion  hsa04510+3725  
GnRH signaling pathway  hsa04912+3725  
Herpes simplex infection  hsa05168+3725  
HTLV-I infection  hsa05166+3725  
Influenza A  hsa05164+3725  
Leishmaniasis  hsa05140+3725  
MAPK signaling pathway  hsa04010+3725  
Neurotrophin signaling pathway  hsa04722+3725  
Osteoclast differentiation  hsa04380+3725  
Pathways in cancer  hsa05200+3725  
Pertussis  hsa05133+3725  
Renal cell carcinoma  hsa05211+3725  
Rheumatoid arthritis  hsa05323+3725  
Salmonella infection  hsa05132+3725  
T cell receptor signaling pathway  hsa04660+3725  
Toll-like receptor signaling pathway  hsa04620+3725  
Wnt signaling pathway  hsa04310+3725  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Immune System  REACT_6900  
TRAF6 Mediated Induction of proinflammatory cytokines  REACT_6782  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: C-jun
GenomeRNAi: 3725
PRO: PR:P05412