POLR3D - DNA-directed RNA polymerase III subunit RPC4 - human protein (Function)
 
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POLR3D »  DNA-directed RNA polymerase III subunit RPC4  (RNA polymerase III subunit C4)
 
Protein also known as:  DNA-directed RNA polymerase III subunit D.
Gene name:  POLR3D
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
Contributes to RNA polymerase III activitydefinition[GO:0001056] silver  
  • IBARefGenome
GO biological process 
Defense response to virusdefinition[GO:0051607]  
  • IEAUniProtKB KW
Positive regulation of innate immune responsedefinition[GO:0045089]  
1
  • IDAUniProtKB
Positive regulation of interferon-beta productiondefinition[GO:0032728]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytosolic DNA-sensing pathway  hsa04623+661  
Metabolic pathways  hsa01100+661  
Purine metabolism  hsa00230+661  
Pyrimidine metabolism  hsa00240+661  
RNA polymerase  hsa03020+661  
According to Reactome, this protein belongs to the following pathways:
RNA Polymerase III Abortive And Retractive Initiation  REACT_22339  
RNA Polymerase III Chain Elongation  REACT_756  
RNA Polymerase III Transcription Initiation From Type 1 Promoter  REACT_347  
RNA Polymerase III Transcription Initiation From Type 2 Promoter  REACT_1036  
RNA Polymerase III Transcription Initiation From Type 3 Promoter  REACT_571  
RNA Polymerase III Transcription Termination  REACT_63  
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Transcription  definition   [KW-0804]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: POLR3D
GenomeRNAi: 661
PRO: PR:P05423