SSB - Lupus La protein - human protein (Function)
 
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Protein
Gene
References

 
SSB »  Lupus La protein
 
Protein also known as:  Sjoegren syndrome type B antigen (SS-B).
Gene name:  SSB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed3192525, PubMed2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed12384597).  
4
  • UniProtKB
GO molecular function 
mRNA bindingdefinition[GO:0003729]  
1
  • PINC
Nucleotide bindingdefinition[GO:0000166] silver  
1
  • InterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
tRNA bindingdefinition[GO:0000049]  
1
  • PINC
GO biological process 
Histone mRNA metabolic processdefinition[GO:0008334]  
1
  • PINC
tRNA modificationdefinition[GO:0006400]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Systemic lupus erythematosus  hsa05322+6741  
According to Reactome, this protein belongs to the following pathways:
RNA Polymerase III Abortive And Retractive Initiation  R-HSA-749476  
RNA Polymerase III Transcription Termination  R-HSA-73980  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Sjogren_syndrome_antigen_B
GenomeRNAi: 6741
PRO: PR:P05455