TFAP2A - Transcription factor AP-2-alpha - human protein (Function)
 
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TFAP2A »  Transcription factor AP-2-alpha  (AP2-alpha)
 
Protein also known as:  Activating enhancer-binding protein 2-alpha.
Gene name:  TFAP2A
Family name: AP-2
Entry whose protein(s) existence is based on evidence at protein level
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1 146 4
GENE REF ISO

Function

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Overview 
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.  
3
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • Ortholog Curator
Core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000987]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
9
  • IntAct
  • UniProtKB
Protein dimerization activitydefinition[GO:0046983]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
2
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activitydefinition[GO:0000982]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
3
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
2
  • UniProtKB
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979]  
1
  • UniProtKB
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980] silver  
1
  • Ortholog Compara
RNA polymerase II transcription coactivator activitydefinition[GO:0001105] silver  
1
  • Ortholog Compara
RNA polymerase II transcription corepressor activitydefinition[GO:0001106] silver  
1
  • Ortholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
2
  • UniProtKB
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • UniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
3
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • UniProtKB
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976]  
1
  • UniProtKB
GO biological process 
Anterior neuropore closuredefinition[GO:0021506] silver  
1
  • Ortholog Compara
Basement membrane organizationdefinition[GO:0071711] silver  
1
  • Ortholog Compara
Bone morphogenesisdefinition[GO:0060349]  
1
  • Ortholog Curator
Cellular response to iron iondefinition[GO:0071281]  
1
  • UniProtKB
Cornea development in camera-type eyedefinition[GO:0061303] silver  
1
  • Ortholog Compara
Embryonic body morphogenesisdefinition[GO:0010172] silver  
1
  • Ortholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701]  
1
  • Ortholog Curator
Embryonic forelimb morphogenesisdefinition[GO:0035115]  
1
  • Ortholog Curator
Embryonic pattern specificationdefinition[GO:0009880] silver  
1
  • Ortholog Compara
Epidermis morphogenesisdefinition[GO:0048730] silver  
1
  • Ortholog Compara
Eyelid development in camera-type eyedefinition[GO:0061029]  
1
  • Ortholog Curator
Face morphogenesisdefinition[GO:0060325] silver  
1
  • Ortholog Compara
Forebrain neuron developmentdefinition[GO:0021884] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472]  
1
  • UniProtKB
Keratinocyte developmentdefinition[GO:0003334] silver  
1
  • Ortholog Compara
Kidney developmentdefinition[GO:0001822]  
1
  • UniProtKB
Lens induction in camera-type eyedefinition[GO:0060235] silver  
1
  • Ortholog Compara
Metanephric nephron developmentdefinition[GO:0072210] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0042059] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of reactive oxygen species metabolic processdefinition[GO:2000378]  
1
  • UniProtKB
Negative regulation of transcription by competitive promoter bindingdefinition[GO:0010944]  
2
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
3
  • UniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Neural crest cell developmentdefinition[GO:0014032] silver  
1
  • Ortholog Compara
Oculomotor nerve formationdefinition[GO:0021623]  
1
  • Ortholog Curator
Optic cup structural organizationdefinition[GO:0003409]  
1
  • Ortholog Curator
Optic vesicle morphogenesisdefinition[GO:0003404]  
1
  • Ortholog Curator
Outflow tract morphogenesisdefinition[GO:0003151] silver  
1
  • Ortholog Compara
Palate developmentdefinition[GO:0060021]  
1
  • UniProtKB
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • UniProtKB
Positive regulation of cell migrationdefinition[GO:0030335] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • Ortholog Curator
Positive regulation of neuron apoptotic processdefinition[GO:0043525]  
1
  • UniProtKB
Positive regulation of tooth mineralizationdefinition[GO:0070172]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
4
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • UniProtKB
  • Ortholog Curator
Regulation of cell differentiationdefinition[GO:0045595]  
1
  • UniProtKB
Regulation of neuron differentiationdefinition[GO:0045664] silver  
1
  • Ortholog Compara
Retina layer formationdefinition[GO:0010842]  
1
  • UniProtKB
Sensory perception of sounddefinition[GO:0007605]  
1
  • UniProtKB
Sympathetic nervous system developmentdefinition[GO:0048485] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
2
  • GOC
Trigeminal nerve developmentdefinition[GO:0021559]  
1
  • Ortholog Curator
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TFAP2A
GenomeRNAi: 7020
PRO: PR:P05549