KRT18 - Keratin, type I cytoskeletal 18 - human protein (Function)
 
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KRT18 »  Keratin, type I cytoskeletal 18
 
Protein also known as:  Cell proliferation-inducing gene 46 protein.
Gene name:  KRT18
Family name: Intermediate filament
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.  
8
  • UniProtKB
GO molecular function 
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • HGNC
  • UniProtKB
Scaffold protein bindingdefinition[GO:0097110]  
1
  • BHF-UCL
Structural molecule activitydefinition[GO:0005198] silver  
1
  • InterPro 2 GO
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • PINC
Cell cycledefinition[GO:0007049]  
1
  • UniProtKB KW
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191] silver  
1
  • Ortholog Compara
Golgi to plasma membrane CFTR protein transportdefinition[GO:0043000]  
1
  • UniProtKB
Hepatocyte apoptotic processdefinition[GO:0097284] silver  
1
  • Ortholog Compara
Intermediate filament cytoskeleton organizationdefinition[GO:0045104]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Tumor necrosis factor-mediated signaling pathwaydefinition[GO:0033209] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Pathogenic Escherichia coli infection  hsa05130+3875  
Note 
There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).  
1
  • UniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Keratin_18
GenomeRNAi: 3875
PRO: PR:P05783