FYN - Tyrosine-protein kinase Fyn - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
FYN »  Tyrosine-protein kinase Fyn   [ EC 2.7.10.2 ]
 
Protein also known as:  Proto-oncogene c-Fyn.
Gene name:  FYN
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 140 3
GENE REF ISO

Function

 show evidences
Overview 
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.  
20
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
CD4 receptor bindingdefinition[GO:0042609] silver  
1
  • Ortholog Compara
CD8 receptor bindingdefinition[GO:0042610] silver  
1
  • Ortholog Compara
Ephrin receptor bindingdefinition[GO:0046875]  
1
  • UniProtKB
G-protein coupled receptor bindingdefinition[GO:0001664] silver  
1
  • Ortholog Compara
Glycoprotein bindingdefinition[GO:0001948]  
1
  • BHF-UCL
Growth factor receptor bindingdefinition[GO:0070851]  
1
  • UniProtKB
Ion channel bindingdefinition[GO:0044325] silver  
1
  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
2
  • UniProtKB
  • RefGenome
Peptide hormone receptor bindingdefinition[GO:0051428] silver  
1
  • Ortholog Compara
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
40
  • IntAct
  • UniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • UniProtKB
T cell receptor bindingdefinition[GO:0042608] silver  
1
  • Ortholog Compara
Tubulin bindingdefinition[GO:0015631] silver  
1
  • Ortholog Compara
GO biological process 
Activated T cell proliferationdefinition[GO:0050798] silver  
1
  • Ortholog Compara
Adaptive immune responsedefinition[GO:0002250]  
1
  • UniProtKB KW
Calcium ion transportdefinition[GO:0006816]  
1
  • UniProtKB
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Cell migrationdefinition[GO:0016477]  
1
  • RefGenome
Cellular response to peptide hormone stimulusdefinition[GO:0071375]  
1
  • RefGenome
Cellular response to platelet-derived growth factor stimulusdefinition[GO:0036120] silver  
1
  • Ortholog Compara
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560] silver  
1
  • Ortholog Compara
Dendrite morphogenesisdefinition[GO:0048813] silver  
1
  • Ortholog Compara
Detection of mechanical stimulus involved in sensory perception of paindefinition[GO:0050966] silver  
1
  • Ortholog Compara
Feeding behaviordefinition[GO:0007631]  
1
  • PINC
Forebrain developmentdefinition[GO:0030900] silver  
1
  • Ortholog Compara
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Intracellular signal transductiondefinition[GO:0035556]  
1
  • PINC
Learningdefinition[GO:0007612]  
1
  • PINC
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of protein catabolic processdefinition[GO:0042177] silver  
1
  • Ortholog Compara
Negative regulation of protein ubiquitinationdefinition[GO:0031397] silver  
1
  • Ortholog Compara
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • RefGenome
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123] silver  
1
  • Ortholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
1
  • Ortholog Compara
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068] silver  
1
  • Ortholog Compara
Positive regulation of protein localization to nucleusdefinition[GO:1900182] silver  
1
  • Ortholog Compara
Positive regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042523] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • RefGenome
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Regulation of cell shapedefinition[GO:0008360] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
T cell activationdefinition[GO:0042110]  
1
  • RefGenome
T cell receptor signaling pathwaydefinition[GO:0050852]  
1
  • UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
It requires the following cofactor
 Mn(2+)  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+2534  
Axon guidance  hsa04360+2534  
Cholinergic synapse  hsa04725+2534  
Fc epsilon RI signaling pathway  hsa04664+2534  
Focal adhesion  hsa04510+2534  
Measles  hsa05162+2534  
Natural killer cell mediated cytotoxicity  hsa04650+2534  
Osteoclast differentiation  hsa04380+2534  
Pathogenic Escherichia coli infection  hsa05130+2534  
Prion diseases  hsa05020+2534  
T cell receptor signaling pathway  hsa04660+2534  
Viral myocarditis  hsa05416+2534  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  R-HSA-983695  
CD209 (DC-SIGN) signaling  R-HSA-5621575  
CD28 co-stimulation  R-HSA-389356  
CD28 dependent PI3K/Akt signaling  R-HSA-389357  
CD28 dependent Vav1 pathway  R-HSA-389359  
Cell surface interactions at the vascular wall  R-HSA-202733  
Constitutive Signaling by Aberrant PI3K in Cancer  R-HSA-2219530  
CRMPs in Sema3A signaling  R-HSA-399956  
CTLA4 inhibitory signaling  R-HSA-389513  
DAP12 signaling  R-HSA-2424491  
DCC mediated attractive signaling  R-HSA-418885  
Dectin-2 family  R-HSA-5621480  
EPH-ephrin mediated repulsion of cells  R-HSA-3928665  
EPH-Ephrin signaling  R-HSA-2682334  
EPHA-mediated growth cone collapse  R-HSA-3928663  
EPHB-mediated forward signaling  R-HSA-3928662  
Ephrin signaling  R-HSA-3928664  
FCGR activation  R-HSA-2029481  
GPVI-mediated activation cascade  R-HSA-114604  
NCAM signaling for neurite out-growth  R-HSA-375165  
Nef and signal transduction  R-HSA-164944  
Nephrin interactions  R-HSA-373753  
Netrin mediated repulsion signals  R-HSA-418886  
PECAM1 interactions  R-HSA-210990  
PIP3 activates AKT signaling  R-HSA-1257604  
Platelet Adhesion to exposed collagen  R-HSA-75892  
RAF/MAP kinase cascade  R-HSA-5673001  
Regulation of KIT signaling  R-HSA-1433559  
Regulation of signaling by CBL  R-HSA-912631  
Role of LAT2/NTAL/LAB on calcium mobilization  R-HSA-2730905  
Sema3A PAK dependent Axon repulsion  R-HSA-399954  
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion  R-HSA-399955  
Signaling by ERBB2  R-HSA-1227986  
Signaling by SCF-KIT  R-HSA-1433557  
VEGFA-VEGFR2 Pathway  R-HSA-4420097  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: FYN
GenomeRNAi: 2534
PRO: PR:P06241
Chemistry
GuidetoPHARMACOLOGY: 2026