BCHE - Cholinesterase - human protein (Function)
 
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BCHE »  Cholinesterase   [ EC 3.1.1.8 ]
 
Protein also known as:  Acylcholine acylhydrolase.
Gene name:  BCHE
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.  
2
  • CuratedUniProtKB
GO molecular function 
Acetylcholinesterase activitydefinition[GO:0003990]  
  • ISSOrtholog Curator
  • IBARefGenome
Beta-amyloid bindingdefinition[GO:0001540]  
1
  • NASUniProtKB
Catalytic activitydefinition[GO:0003824]  
1
  • NASUniProtKB
Choline bindingdefinition[GO:0033265] silver  
  • IEAOrtholog Compara
Cholinesterase activitydefinition[GO:0004104]  
1
  • IDAUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • NASUniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
GO biological process 
Choline metabolic processdefinition[GO:0019695] silver  
  • IBARefGenome
Cocaine metabolic processdefinition[GO:0050783]  
1
  • TASUniProtKB
Learningdefinition[GO:0007612] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of synaptic transmissiondefinition[GO:0050805] silver  
  • IEAOrtholog Compara
Neuroblast differentiationdefinition[GO:0014016] silver  
  • IEAOrtholog Compara
Response to alkaloiddefinition[GO:0043279] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to folic aciddefinition[GO:0051593] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Synaptic transmission, cholinergicdefinition[GO:0007271] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.1.8: An acylcholine + H(2)O choline + a carboxylate.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by mercury. Inhibited by Tabun. Tabun forms a covalent adduct with Ser-226 that becomes irreversible upon aging.  
3
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Neurotransmitter Clearance In The Synaptic Cleft  REACT_13583  
Synthesis of PC  REACT_121238  
Synthesis, secretion, and deacylation of Ghrelin  REACT_19189  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Serine esterase  definition   [KW-0719]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P06276
Other
GeneWiki: Butyrylcholinesterase
GenomeRNAi: 590
PRO: PR:P06276
Chemistry
GuidetoPHARMACOLOGY: 2471