GLA - Alpha-galactosidase A - human protein (Function)
 
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GLA »  Alpha-galactosidase A   [ EC 3.2.1.22 ]
 
Protein also known as:  Alpha-D-galactoside galactohydrolase; International Nonproprietary Name Agalsidase.
Gene name:  GLA
Family name: Glycosyl hydrolase 27
Entry whose protein(s) existence is based on evidence at protein level
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1 136 1
GENE REF ISO

Function

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GO molecular function 
Alpha-galactosidase activitydefinition[GO:0004557]  
2
  • IMPUniProtKB
Catalytic activitydefinition[GO:0003824]  
1
  • IDAUniProtKB
Galactoside bindingdefinition[GO:0016936] silver  
  • IEAOrtholog Compara
Hydrolase activitydefinition[GO:0016787]  
1
  • TASUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Raffinose alpha-galactosidase activitydefinition[GO:0052692]  
  • IEAEC 2 GO
Receptor bindingdefinition[GO:0005102]  
1
  • IDAUniProtKB
GO biological process 
Glycoside catabolic processdefinition[GO:0016139] silver  
  • IBARefGenome
Glycosphingolipid catabolic processdefinition[GO:0046479]  
1
  • TASUniProtKB
Glycosylceramide catabolic processdefinition[GO:0046477]  
  • IBARefGenome
  • ISSOrtholog Curator
Negative regulation of nitric oxide biosynthetic processdefinition[GO:0045019]  
  • ISSOrtholog Curator
Negative regulation of nitric-oxide synthase activitydefinition[GO:0051001]  
  • ISSOrtholog Curator
Oligosaccharide metabolic processdefinition[GO:0009311]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.1.22: Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 27  GH27  
Pathways 
According to KEGG, this protein belongs to the following pathways:
Galactose metabolism  hsa00052+2717  
Glycerolipid metabolism  hsa00561+2717  
Glycosphingolipid biosynthesis - globo series  hsa00603+2717  
Lysosome  hsa04142+2717  
Sphingolipid metabolism  hsa00600+2717  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P06280
Other
GeneWiki: Alpha-galactosidase
GenomeRNAi: 2717
PRO: PR:P06280