GSN - Gelsolin - human protein (Function)
 
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GSN »  Gelsolin
 
Protein also known as:  Actin-depolymerizing factor (ADF).
Gene name:  GSN
Family name: Villin/gelsolin
Entry whose protein(s) existence is based on evidence at protein level
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1 151 4
GENE REF ISO

Function

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Overview 
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.  
2
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • UniProtKB KW
Calcium ion bindingdefinition[GO:0005509]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Actin filament polymerizationdefinition[GO:0030041]  
2
  • UniProtKB
  • Ortholog Curator
Actin filament severingdefinition[GO:0051014]  
2
  • UniProtKB
  • Ortholog Curator
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Barbed-end actin filament cappingdefinition[GO:0051016]  
1
  • PINC
Cellular response to cadmium iondefinition[GO:0071276] silver  
1
  • Ortholog Compara
Cilium morphogenesisdefinition[GO:0060271]  
1
  • UniProtKB
Oligodendrocyte developmentdefinition[GO:0014003] silver  
1
  • Ortholog Compara
Phosphatidylinositol-mediated signalingdefinition[GO:0048015] silver  
1
  • Ortholog Compara
Regulation of cell adhesiondefinition[GO:0030155] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to folic aciddefinition[GO:0051593] silver  
1
  • Ortholog Compara
Tissue regenerationdefinition[GO:0042246] silver  
1
  • Ortholog Compara
Vesicle-mediated transportdefinition[GO:0016192] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fc gamma R-mediated phagocytosis  hsa04666+2934  
Regulation of actin cytoskeleton  hsa04810+2934  
According to Reactome, this protein belongs to the following pathways:
Amyloids  REACT_75925  
Caspase-mediated cleavage of cytoskeletal proteins  REACT_13541  
 

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Molecular function 
Actin capping  definition   [KW-0117]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Gelsolin
GenomeRNAi: 2934
PRO: PR:P06396