GSN - Gelsolin - human protein (Function)
 
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Protein
Gene
References

 
GSN »  Gelsolin
 
Protein also known as:  Actin-depolymerizing factor (ADF).
Gene name:  GSN
Family name: Villin/gelsolin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 161 4
GENE REF ISO

Function

 show evidences
Overview 
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.  
2
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
2
  • UniProtKB
Calcium ion bindingdefinition[GO:0005509]  
1
  • UniProtKB
Myosin II bindingdefinition[GO:0045159]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
  • IntAct
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
GO biological process 
Actin filament cappingdefinition[GO:0051693]  
2
  • UniProtKB
  • Ortholog Curator
Actin filament polymerizationdefinition[GO:0030041]  
3
  • UniProtKB
  • Ortholog Curator
Actin filament reorganizationdefinition[GO:0090527]  
1
  • UniProtKB
Actin filament severingdefinition[GO:0051014]  
3
  • UniProtKB
  • Ortholog Curator
Actin nucleationdefinition[GO:0045010] silver  
1
  • InterPro 2 GO
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Amyloid fibril formationdefinition[GO:1990000]  
2
  • UniProtKB
Barbed-end actin filament cappingdefinition[GO:0051016] silver  
1
  • InterPro 2 GO
Cellular response to cadmium iondefinition[GO:0071276] silver  
1
  • Ortholog Compara
Cilium morphogenesisdefinition[GO:0060271]  
1
  • UniProtKB
Not  Extracellular matrix disassemblydefinition[GO:0022617]  
1
  • UniProtKB
Hepatocyte apoptotic processdefinition[GO:0097284]  
1
  • UniProtKB
Negative regulation of viral entry into host celldefinition[GO:0046597]  
1
  • UniProtKB
Oligodendrocyte developmentdefinition[GO:0014003] silver  
1
  • Ortholog Compara
Phagocytosis, engulfmentdefinition[GO:0006911]  
1
  • Ortholog Curator
Phosphatidylinositol-mediated signalingdefinition[GO:0048015] silver  
1
  • Ortholog Compara
Positive regulation of actin nucleationdefinition[GO:0051127]  
1
  • UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaydefinition[GO:2001269]  
1
  • UniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • UniProtKB
Positive regulation of keratinocyte apoptotic processdefinition[GO:1902174]  
1
  • UniProtKB
Positive regulation of protein processing in phagocytic vesicledefinition[GO:1903923]  
1
  • Ortholog Curator
Protein destabilizationdefinition[GO:0031648]  
1
  • UniProtKB
Regulation of establishment of T cell polaritydefinition[GO:1903903]  
1
  • UniProtKB
Regulation of plasma membrane raft polarizationdefinition[GO:1903906]  
1
  • UniProtKB
Regulation of podosome assemblydefinition[GO:0071801]  
1
  • UniProtKB
Regulation of receptor clusteringdefinition[GO:1903909]  
1
  • UniProtKB
Regulation of wound healing, spreading of epidermal cellsdefinition[GO:1903689]  
2
  • UniProtKB
Renal protein absorptiondefinition[GO:0097017]  
1
  • UniProtKB
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to folic aciddefinition[GO:0051593] silver  
1
  • Ortholog Compara
Sequestering of actin monomersdefinition[GO:0042989]  
1
  • UniProtKB
Striated muscle atrophydefinition[GO:0014891]  
1
  • UniProtKB
Tissue regenerationdefinition[GO:0042246] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fc gamma R-mediated phagocytosis  hsa04666+2934  
Regulation of actin cytoskeleton  hsa04810+2934  
According to Reactome, this protein belongs to the following pathways:
Amyloids  REACT_75925  
Caspase-mediated cleavage of cytoskeletal proteins  REACT_13541  
 

Keywords

Biological process 
Cilium biogenesis/degradation  definition   [KW-0970]
Molecular function 
Actin capping  definition   [KW-0117]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Gelsolin
GenomeRNAi: 2934
PRO: PR:P06396